Reaction Details |
| Report a problem with these data |
Target | Polyunsaturated fatty acid lipoxygenase ALOX15 |
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Ligand | BDBM22269 |
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Substrate/Competitor | BDBM22231 |
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Meas. Tech. | Enzyme Inhibition Assay |
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IC50 | >10000±n/a nM |
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Citation | Weinstein, DS; Liu, W; Gu, Z; Langevine, C; Ngu, K; Fadnis, L; Combs, DW; Sitkoff, D; Ahmad, S; Zhuang, S; Chen, X; Wang, FL; Loughney, DA; Atwal, KS; Zahler, R; Macor, JE; Madsen, CS; Murugesan, N Tryptamine and homotryptamine-based sulfonamides as potent and selective inhibitors of 15-lipoxygenase. Bioorg Med Chem Lett15:1435-40 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Polyunsaturated fatty acid lipoxygenase ALOX15 |
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Name: | Polyunsaturated fatty acid lipoxygenase ALOX15 |
Synonyms: | 15-Lipoxygenase | ALOX15 | Arachidonate 15-lipoxygenase | Erythroid cell-specific 15-lipoxygenase | LOX15_RABIT | Omega-6 lipoxygenase |
Type: | Enzyme |
Mol. Mass.: | 75309.71 |
Organism: | Oryctolagus cuniculus (rabbit) |
Description: | 15-LO enzyme was purified from phenylhydrazine treated rabbits. |
Residue: | 663 |
Sequence: | MGVYRVCVSTGASIYAGSKNKVELWLVGQHGEVELGSCLRPTRNKEEEFKVNVSKYLGSL
LFVRLRKKHFLKEDAWFCNWISVQALGAAEDKYWFPCYRWVVGDGVQSLPVGTGCTTVGD
PQGLFQKHREQELEERRKLYQWGSWKEGLILNVAGSKLTDLPVDERFLEDKKIDFEASLA
WGLAELALKNSLNILAPWKTLDDFNRIFWCGRSKLARRVRDSWQEDSLFGYQFLNGANPM
LLRRSVQLPARLVFPPGMEELQAQLEKELKAGTLFEADFALLDNIKANVILYCQQYLAAP
LVMLKLQPDGKLMPMVIQLHLPKIGSSPPPLFLPTDPPMVWLLAKCWVRSSDFQVHELNS
HLLRGHLMAEVFTVATMRCLPSIHPVFKLIVPHLRYTLEINVRARNGLVSDFGIFDQIMS
TGGGGHVQLLQQAGAFLTYRSFCPPDDLADRGLLGVESSFYAQDALRLWEIISRYVQGIM
GLYYKTDEAVRDDLELQSWCREITEIGLQGAQKQGFPTSLQSVAQACHFVTMCIFTCTGQ
HSSIHLGQLDWFTWVPNAPCTMRLPPPTTKDATLETVMATLPNLHQSSLQMSIVWQLGRD
QPIMVPLGQHQEEYFSGPEPRAVLEKFREELAIMDKEIEVRNEKLDIPYEYLRPSIVENS
VAI
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BDBM22269 |
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BDBM22231 |
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Name | BDBM22269 |
Synonyms: | 4-ethyl-N-[2-(1H-indol-3-yl)ethyl]benzene-1-sulfonamide | tryptamine sulfonamide, 7 |
Type | Small organic molecule |
Emp. Form. | C18H20N2O2S |
Mol. Mass. | 328.429 |
SMILES | CCc1ccc(cc1)S(=O)(=O)NCCc1c[nH]c2ccccc12 |
Structure |
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