| Reaction Details |
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 | Report a problem with these data |
| Target | Trifunctional purine biosynthetic protein adenosine-3 |
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| Ligand | BDBM22588 |
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| Substrate/Competitor | BDBM22589 |
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| Meas. Tech. | GAR Tfase Activity Assay |
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| pH | 7.5±n/a |
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| Temperature | 299.15±n/a K |
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| Ki | 4800±n/a nM |
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| Citation |  Xu, L; Chong, Y; Hwang, I; D'Onofrio, A; Amore, K; Beardsley, GP; Li, C; Olson, AJ; Boger, DL; Wilson, IA Structure-based design, synthesis, evaluation, and crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase. J Biol Chem282:13033-46 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Trifunctional purine biosynthetic protein adenosine-3 |
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| Name: | Trifunctional purine biosynthetic protein adenosine-3 |
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| Synonyms: | GAR Tfase | GAR transformylase | GART | Glycinamide ribonucleotide formyltransferase (GARFTase) | Glycinamide ribonucleotide transformylase (GAR Tfase) | PGFT | PRGS | PUR2_HUMAN | Thymidylate synthase/GAR transformylase/AICAR transformylase |
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| Type: | Protein |
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| Mol. Mass.: | 107768.47 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P22102 |
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| Residue: | 1010 |
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| Sequence: | MAARVLIIGSGGREHTLAWKLAQSHHVKQVLVAPGNAGTACSEKISNTAISISDHTALAQ
FCKEKKIEFVVVGPEAPLAAGIVGNLRSAGVQCFGPTAEAAQLESSKRFAKEFMDRHGIP
TAQWKAFTKPEEACSFILSADFPALVVKASGLAAGKGVIVAKSKEEACKAVQEIMQEKAF
GAAGETIVIEELLDGEEVSCLCFTDGKTVAPMPPAQDHKRLLEGDGGPNTGGMGAYCPAP
QVSNDLLLKIKDTVLQRTVDGMQQEGTPYTGILYAGIMLTKNGPKVLEFNCRFGDPECQV
ILPLLKSDLYEVIQSTLDGLLCTSLPVWLENHTALTVVMASKGYPGDYTKGVEITGFPEA
QALGLEVFHAGTALKNGKVVTHGGRVLAVTAIRENLISALEEAKKGLAAIKFEGAIYRKD
VGFRAIAFLQQPRSLTYKESGVDIAAGNMLVKKIQPLAKATSRSGCKVDLGGFAGLFDLK
AAGFKDPLLASGTDGVGTKLKIAQLCNKHDTIGQDLVAMCVNDILAQGAEPLFFLDYFSC
GKLDLSVTEAVVAGIAKACGKAGCALLGGETAEMPDMYPPGEYDLAGFAVGAMERDQKLP
HLERITEGDVVVGIASSGLHSNGFSLVRKIVAKSSLQYSSPAPDGCGDQTLGDLLLTPTR
IYSHSLLPVLRSGHVKAFAHITGGGLLENIPRVLPEKLGVDLDAQTWRIPRVFSWLQQEG
HLSEEEMARTFNCGVGAVLVVSKEQTEQILRDIQQHKEEAWVIGSVVARAEGSPRVKVKN
LIESMQINGSVLKNGSLTNHFSFEKKKARVAVLISGTGSNLQALIDSTREPNSSAQIDIV
ISNKAAVAGLDKAERAGIPTRVINHKLYKNRVEFDSAIDLVLEEFSIDIVCLAGFMRILS
GPFVQKWNGKMLNIHPSLLPSFKGSNAHEQALETGVTVTGCTVHFVAEDVDAGQIILQEA
VPVKRGDTVATLSERVKLAEHKIFPAALQLVASGTVQLGENGKICWVKEE
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| BDBM22588 |
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| BDBM22589 |
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| Name | BDBM22588 |
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| Synonyms: | Nucleotide, 3 | {[(2R,3S,4R,5R)-3,4-dihydroxy-5-(2,2,4-trioxo-1H,3H,4H,7H-2,1,3,5,7-imidazo[4,5-c][1,2,6]thiadiazin-7-yl)oxolan-2-yl]methoxy}phosphonic acid |
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| Type | Nucleoside or nucleotide |
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| Emp. Form. | C9H13N4O10PS |
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| Mol. Mass. | 400.259 |
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| SMILES | O[C@@H]1[C@@H](COP(O)(O)=O)O[C@H]([C@@H]1O)n1cnc2c1NS(=O)(=O)NC2=O |r| |
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| Structure | 
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