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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Interleukin-1 receptor-associated kinase 4 | ||
| Ligand | BDBM380572 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Kinase Assay | ||
| IC50 | 31.0±n/a nM | ||
| Citation |  Altman, MD; Brubaker, JD; Childers, ML; Donofrio, A; Fischmann, T; Gibeau, CR; Kattar, SD; Lesburg, CA; Lim, J; MacLean, JK; Mansoor, UF; Northrup, AB; Sanders, JM; Smith, GF Inhibitors of IRAK4 activity US Patent US9926330 Publication Date 3/27/2018 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Interleukin-1 receptor-associated kinase 4 | |||
| Name: | Interleukin-1 receptor-associated kinase 4 | ||
| Synonyms: | IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64 | ||
| Type: | Protein | ||
| Mol. Mass.: | 51519.08 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q9NWZ3 | ||
| Residue: | 460 | ||
| Sequence: |
| ||
| BDBM380572 | |||
| n/a | |||
| Name | BDBM380572 | ||
| Synonyms: | US9926330, 2-25 | trans-N- (cyclopropylmethyl)-N'-(6- methylquinazolin-4- yl)cyclohexane-1,4- diamine | ||
| Type | Small organic molecule | ||
| Emp. Form. | C19H26N4 | ||
| Mol. Mass. | 310.4365 | ||
| SMILES | Cc1ccc2ncnc(N[C@H]3CC[C@@H](CC3)NCC3CC3)c2c1 |r,wU:13.16,wD:10.9,(-2.59,6.77,;-3.36,5.44,;-4.9,5.44,;-5.67,4.1,;-4.9,2.77,;-5.67,1.44,;-4.9,.1,;-3.36,.1,;-2.59,1.44,;-1.05,1.44,;-.28,.1,;-1.05,-1.23,;-.28,-2.56,;1.26,-2.56,;2.03,-1.23,;1.26,.1,;2.03,-3.9,;3.57,-3.9,;4.34,-5.23,;4.34,-6.77,;5.67,-6,;-3.36,2.77,;-2.59,4.1,)| | ||
| Structure | 
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