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TargetTGF-beta receptor type-1 [T204D]
LigandBDBM282820
Substrate/Competitorn/a
Meas. Tech.Biological Assay
IC50 0.600±n/a nM
Citation Kinsella, TGelman, MHong, HDarwish, ISSingh, RYu, JBorzilleri, RMVelaparthi, ULiu, PDarne, CPRahaman, HWarrier, JS TGF-β inhibitors US Patent US10287295 Publication Date 5/14/2019
More Info.:Get all data from this article,  Assay Method
 
TGF-beta receptor type-1 [T204D]
Name:TGF-beta receptor type-1 [T204D]
Synonyms:ALK5 | SKR4 | TGF-beta receptor type-1 (T204D) | TGF-betaR1 T204D | TGFBR1 | TGFBR1T204D | TGFR-1 (T204D) | TGFR1_HUMAN
Type:n/a
Mol. Mass.:55981.22
Organism:Homo sapiens (Human)
Description:P36897[T204D]
Residue:503
Sequence:
MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTE
TTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPG
LGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDL
IYDMTTSGSGSGLPLLVQRTIARDIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREER
SWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVE
GMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDS
ATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGI
HEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGA
ARLTALRIKKTLSQLSQQEGIKM
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  Blast E-value cutoff:
BDBM282820
n/a
NameBDBM282820
Synonyms:6-(4-(4-fluorophenyl)-1-(3- (hydroxymethyl)cyclobutyl)-1H-imidazol-5- yl)imidazo[1,2-b]pyridazine-3-carbonitrile | US10287295, Example 27' | US11352360, Example 27' | US9884868, Example 27'
TypeSmall organic molecule
Emp. Form.C21H17FN6O
Mol. Mass.388.3977
SMILESOCC1CC(C1)n1cnc(c1-c1ccc2ncc(C#N)n2n1)-c1ccc(F)cc1 |(-4.26,-4.53,;-2.93,-5.3,;-1.59,-4.53,;-1.19,-3.04,;.29,-3.44,;-.1,-4.93,;1.63,-2.67,;3.09,-3.14,;4,-1.9,;3.09,-.65,;1.63,-1.13,;.29,-.36,;.29,1.18,;-1.04,1.95,;-2.37,1.18,;-3.84,1.66,;-4.74,.41,;-3.84,-.83,;-4.31,-2.3,;-4.79,-3.76,;-2.37,-.36,;-1.04,-1.13,;3.49,.83,;4.98,1.23,;5.38,2.72,;4.29,3.81,;4.69,5.3,;2.8,3.41,;2.4,1.92,)|
Structure
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