Reaction Details | |||
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Target | TGF-beta receptor type-1 [T204D] | ||
Ligand | BDBM282820 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Biological Assay | ||
IC50 | 0.600±n/a nM | ||
Citation | Kinsella, T; Gelman, M; Hong, H; Darwish, IS; Singh, R; Yu, J; Borzilleri, RM; Velaparthi, U; Liu, P; Darne, CP; Rahaman, H; Warrier, JS TGF-β inhibitors US Patent US10287295 Publication Date 5/14/2019 | ||
More Info.: | Get all data from this article, Assay Method | ||
TGF-beta receptor type-1 [T204D] | |||
Name: | TGF-beta receptor type-1 [T204D] | ||
Synonyms: | ALK5 | SKR4 | TGF-beta receptor type-1 (T204D) | TGF-betaR1 T204D | TGFBR1 | TGFBR1T204D | TGFR-1 (T204D) | TGFR1_HUMAN | ||
Type: | n/a | ||
Mol. Mass.: | 55981.22 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P36897[T204D] | ||
Residue: | 503 | ||
Sequence: |
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BDBM282820 | |||
n/a | |||
Name | BDBM282820 | ||
Synonyms: | 6-(4-(4-fluorophenyl)-1-(3- (hydroxymethyl)cyclobutyl)-1H-imidazol-5- yl)imidazo[1,2-b]pyridazine-3-carbonitrile | US10287295, Example 27' | US11352360, Example 27' | US9884868, Example 27' | ||
Type | Small organic molecule | ||
Emp. Form. | C21H17FN6O | ||
Mol. Mass. | 388.3977 | ||
SMILES | OCC1CC(C1)n1cnc(c1-c1ccc2ncc(C#N)n2n1)-c1ccc(F)cc1 |(-4.26,-4.53,;-2.93,-5.3,;-1.59,-4.53,;-1.19,-3.04,;.29,-3.44,;-.1,-4.93,;1.63,-2.67,;3.09,-3.14,;4,-1.9,;3.09,-.65,;1.63,-1.13,;.29,-.36,;.29,1.18,;-1.04,1.95,;-2.37,1.18,;-3.84,1.66,;-4.74,.41,;-3.84,-.83,;-4.31,-2.3,;-4.79,-3.76,;-2.37,-.36,;-1.04,-1.13,;3.49,.83,;4.98,1.23,;5.38,2.72,;4.29,3.81,;4.69,5.3,;2.8,3.41,;2.4,1.92,)| | ||
Structure |