| Reaction Details |
|---|
 | Report a problem with these data |
| Target | TGF-beta receptor type-1 [T204D] |
|---|
| Ligand | BDBM282932 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Biological Assay |
|---|
| IC50 | 0.600±n/a nM |
|---|
| Citation |  Kinsella, T; Gelman, M; Hong, H; Darwish, IS; Singh, R; Yu, J; Borzilleri, RM; Velaparthi, U; Liu, P; Darne, CP; Rahaman, H; Warrier, JS TGF-β inhibitors US Patent US10287295 Publication Date 5/14/2019 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| TGF-beta receptor type-1 [T204D] |
|---|
| Name: | TGF-beta receptor type-1 [T204D] |
|---|
| Synonyms: | ALK5 | SKR4 | TGF-beta receptor type-1 (T204D) | TGF-betaR1 T204D | TGFBR1 | TGFBR1T204D | TGFR-1 (T204D) | TGFR1_HUMAN |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | 55981.22 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P36897[T204D] |
|---|
| Residue: | 503 |
|---|
| Sequence: | MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTE
TTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPG
LGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDL
IYDMTTSGSGSGLPLLVQRTIARDIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREER
SWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVE
GMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDS
ATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGI
HEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGA
ARLTALRIKKTLSQLSQQEGIKM
|
|
|
|---|
| BDBM282932 |
|---|
| n/a |
|---|
| Name | BDBM282932 |
|---|
| Synonyms: | 6-(1-(2,2-difluoropropyl)-4-(4-fluorophenyl)-1H- imidazol-5-yl)imidazo[1,2-b]pyridazine-3-carboxamide | US10287295, Example 137' | US11352360, Example 137' | US9884868, Example 137' |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H15F3N6O |
|---|
| Mol. Mass. | 400.3572 |
|---|
| SMILES | CC(F)(F)Cn1cnc(c1-c1ccc2ncc(C(N)=O)n2n1)-c1ccc(F)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
