Reaction Details |
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Target | Gag-Pol polyprotein [588-1127,L687I]/[588-1147,L687I] |
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Ligand | BDBM1434 |
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Substrate/Competitor | poly(rA)/oligo(dT) |
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Meas. Tech. | Reverse Transcriptase Assay |
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pH | 7.5±n/a |
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Temperature | 310.15±n/a K |
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Ki | 9000±1000 nM |
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Citation | Butini, S; Brindisi, M; Cosconati, S; Marinelli, L; Borrelli, G; Coccone, SS; Ramunno, A; Campiani, G; Novellino, E; Zanoli, S; Samuele, A; Giorgi, G; Bergamini, A; Mattia, MD; Lalli, S; Galletti, B; Gemma, S; Maga, G Specific Targeting of Highly Conserved Residues in the HIV-1 Reverse Transcriptase Primer Grip Region. 2. Stereoselective Interaction to Overcome the Effects of Drug Resistant Mutations. J Med Chem52:1224-8 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Gag-Pol polyprotein [588-1127,L687I]/[588-1147,L687I] |
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Name: | Gag-Pol polyprotein [588-1127,L687I]/[588-1147,L687I] |
Synonyms: | EC: 2.7.7.49 | HIV-1 Reverse Transcriptase Mutant (L100I) |
Type: | Protein Complex |
Mol. Mass.: | n/a |
Description: | n/a |
Components: | This complex has 2 components. |
Component 1 |
Name: | Gag-Pol polyprotein [588-1147,L687I] |
Synonyms: | HIV-1 Reverse Transcriptase Mutant (L100I) Chain A | POL_HV1H2 | gag-pol |
Type: | Enzyme Subunit |
Mol. Mass.: | 64486.41 |
Organism: | Human immunodeficiency virus type 1 |
Description: | P04585[588-1147,L687I] |
Residue: | 560 |
Sequence: | PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGIKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGIRKVL
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Component 2 |
Name: | Gag-Pol polyprotein [588-1127,L687I] |
Synonyms: | HIV-1 Reverse Transcriptase Mutant (L100I) Chain B | POL_HV1H2 | gag-pol |
Type: | Enzyme Subunit |
Mol. Mass.: | 51337.13 |
Organism: | Human immunodeficiency virus type 1 |
Description: | P04585[588-1127,L687I] |
Residue: | 440 |
Sequence: | PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGIKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETF
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BDBM1434 |
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poly(rA)/oligo(dT) |
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Name: | poly(rA)/oligo(dT) |
Synonyms: | n/a |
Type: | RNA/DNA duplex |
Mol. Mass.: | 358.43 |
Organism: | n/a |
Description: | [3H]-dTTP is co-substrate. |
Residue: | 3 |
Sequence: | |