| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydroorotate dehydrogenase (quinone), mitochondrial [30-395] |
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| Ligand | BDBM28817 |
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| Substrate/Competitor | BDBM14700 |
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| Meas. Tech. | DHODH Inhibition Assay |
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| IC50 | >100000±n/a nM |
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| Citation |  Gujjar, R; Marwaha, A; El Mazouni, F; White, J; White, KL; Creason, S; Shackleford, DM; Baldwin, J; Charman, WN; Buckner, FS; Charman, S; Rathod, PK; Phillips, MA Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in mice. J Med Chem52:1864-72 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Dihydroorotate dehydrogenase (quinone), mitochondrial [30-395] |
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| Name: | Dihydroorotate dehydrogenase (quinone), mitochondrial [30-395] |
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| Synonyms: | DHODH | DHOdehase | Dihydroorotate Dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | PYRD_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 39678.95 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant human DHODH (amino acids 30 to 395) was cloned and expressed in E. coli. |
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| Residue: | 366 |
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| Sequence: | ATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRN
PVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFN
SHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLV
VNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIAS
VVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPI
IGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAI
GADHRR
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| BDBM28817 |
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| BDBM14700 |
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| Name | BDBM28817 |
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| Synonyms: | 5-methyl-N-[4-(trifluoromethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine | DSM74 | triazolopyrimidine-based compound, DSM74 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H10F3N5 |
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| Mol. Mass. | 293.2472 |
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| SMILES | Cc1cc(Nc2ccc(cc2)C(F)(F)F)n2ncnc2n1 |
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| Structure | 
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