Reaction Details | |||
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Target | 5-hydroxytryptamine receptor 7 | ||
Ligand | BDBM29557 | ||
Substrate/Competitor | BDBM21392 | ||
Meas. Tech. | Radioligand Binding Assay (Ki) | ||
pH | 7.4±n/a | ||
Temperature | 310.15±n/a K | ||
Ki | 1820±38 nM | ||
Citation | Paluchowska, MH; Bugno, R; Duszyńska, B; Tatarczyńska, E; Nikiforuk, A; Lenda, T; Chojnacka-Wójcik, E The influence of modifications in imide fragment structure on 5-HT(1A) and 5-HT(7) receptor affinity and in vivo pharmacological properties of some new 1-(m-trifluoromethylphenyl)piperazines. Bioorg Med Chem15:7116-25 (2007) [PubMed] Article | ||
More Info.: | Get all data from this article, Solution Info, Assay Method | ||
5-hydroxytryptamine receptor 7 | |||
Name: | 5-hydroxytryptamine receptor 7 | ||
Synonyms: | 5-HT-7 | 5-HT-X | 5-HT7 | 5-HT7L | 5-HT7S | 5-HT7b | 5HT7 | 5HT7R_HUMAN | HTR7 | Serotonin receptor 7 | ||
Type: | G Protein-Coupled Receptor (GPCR) | ||
Mol. Mass.: | 53573.08 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P34969 | ||
Residue: | 479 | ||
Sequence: |
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BDBM29557 | |||
BDBM21392 | |||
Name | BDBM29557 | ||
Synonyms: | 1-(m-trifluorophenyl)piperazine, 4 | ||
Type | Small organic molecule | ||
Emp. Form. | C21H26F3N3O2 | ||
Mol. Mass. | 409.4452 | ||
SMILES | FC(F)(F)c1cccc(c1)N1CCN(CC1)C1CCC(CC1)N1C(=O)CCC1=O |(9.97,11.47,;11.29,10.68,;12.06,12.02,;12.62,9.9,;10.5,9.37,;11.24,8.02,;10.45,6.7,;8.91,6.73,;8.16,8.08,;8.96,9.39,;6.62,8.08,;5.82,9.39,;4.28,9.34,;3.54,7.99,;4.35,6.68,;5.89,6.72,;2,7.99,;1.23,9.32,;-.31,9.32,;-1.08,7.99,;-.31,6.65,;1.23,6.65,;-2.62,7.99,;-3.15,9.43,;-2.38,10.77,;-4.69,9.37,;-5.1,7.88,;-3.82,7.03,;-3.42,5.54,)| | ||
Structure |