Reaction Details |
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Target | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ |
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Ligand | BDBM31927 |
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Substrate/Competitor | BDBM8737 |
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Meas. Tech. | Enzymatic Inhibition Assay |
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pH | 8±n/a |
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Temperature | 298.15±n/a K |
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IC50 | 1500±250 nM |
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Comments | 94.2% inhibition @ 50 uM. |
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Citation | He, L; Zhang, L; Liu, X; Li, X; Zheng, M; Li, H; Yu, K; Chen, K; Shen, X; Jiang, H; Liu, H Discovering potent inhibitors against the beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ) of Helicobacter pylori: structure-based design, synthesis, bioassay, and crystal structure determination. J Med Chem52:2465-81 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ |
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Name: | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ |
Synonyms: | (3R)-hydroxymyristoyl ACP dehydrase | (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase | FABZ_HELPY | beta-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ) | fabZ |
Type: | Lyase |
Mol. Mass.: | 18198.05 |
Organism: | Helicobacter pylori (Campylobacter pylori) |
Description: | HpfabZ is expressed and purified from E. coli. |
Residue: | 159 |
Sequence: | MEQSHQNLQSQFFIEHILQILPHRYPMLLVDRIIELQANKKIVAYKNITFNEDVFNGHFP
NKPIFPGVLIVEGMAQTGGFLAFTSLWGFDPEIAKTKIVYFMTIDKVKFRIPVTPGDRLE
YHLEVLKHKGMIWQVGGTAQVDGKVVAEAELKAMIAERD
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BDBM31927 |
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BDBM8737 |
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Name | BDBM31927 |
Synonyms: | carbohydrazide derivative, 3j |
Type | Small organic molecule |
Emp. Form. | C14H9Br3N2O3 |
Mol. Mass. | 492.945 |
SMILES | Oc1c(Br)cc(\C=N\NC(=O)c2ccc(Br)cc2)c(O)c1Br |
Structure |
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