Reaction Details |
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Target | HIV-1 protease |
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Ligand | BDBM50124714 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Protease Inhibtion Assay |
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pH | 5.5±0 |
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Ki | 0.021±0.013 nM |
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Citation | Rodgers, JD; Lam, PY; Johnson, BL; Wang, H; Li, R; Ru, Y; Ko, SS; Seitz, SP; Trainor, GL; Anderson, PS; Klabe, RM; Bacheler, LT; Cordova, B; Garber, S; Reid, C; Wright, MR; Chang, CH; Erickson-Viitanen, S Design and selection of DMP 850 and DMP 851: the next generation of cyclic urea HIV protease inhibitors. Chem Biol5:597-608 (1998) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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HIV-1 protease |
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Name: | HIV-1 protease |
Synonyms: | HIV-1 protease wild type |
Type: | Protein |
Mol. Mass.: | 10757.68 |
Organism: | Human immunodeficiency virus |
Description: | O90785 |
Residue: | 99 |
Sequence: | PQITLWQRPLVTVKIGGQLREALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVKQYE
QVLIEICGKKAIGTVLVGPTPVNIIGRNMLTQIGCTLNF
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BDBM50124714 |
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n/a |
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Name | BDBM50124714 |
Synonyms: | (4R,5S,6S,7R)-1-(3-Amino-1H-indazol-5-ylmethyl)-4,7-dibenzyl-3-butyl-5,6-dihydroxy-[1,3]diazepan-2-one | CHEMBL413332 | DMP-851 | DMP851 |
Type | Small organic molecule |
Emp. Form. | C31H37N5O3 |
Mol. Mass. | 527.6572 |
SMILES | CCCCN1[C@H](Cc2ccccc2)[C@H](O)[C@@H](O)[C@@H](Cc2ccccc2)N(Cc2ccc3[nH]nc(N)c3c2)C1=O |
Structure |
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