| Reaction Details |
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 | Report a problem with these data |
| Target | ATP-dependent RNA helicase DHX29 |
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| Ligand | BDBM50239866 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1667495 (CHEMBL4017291) |
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| IC50 | >100000±n/a nM |
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| Citation |  Iwatani-Yoshihara, M; Ito, M; Klein, MG; Yamamoto, T; Yonemori, K; Tanaka, T; Miwa, M; Morishita, D; Endo, S; Tjhen, R; Qin, L; Nakanishi, A; Maezaki, H; Kawamoto, T Discovery of Allosteric Inhibitors Targeting the Spliceosomal RNA Helicase Brr2. J Med Chem60:5759-5771 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| ATP-dependent RNA helicase DHX29 |
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| Name: | ATP-dependent RNA helicase DHX29 |
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| Synonyms: | DDX29 | DEAH box protein 29 | DHX29 | DHX29_HUMAN | Nucleic acid helicase DDXx |
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| Type: | Protein |
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| Mol. Mass.: | 155255.95 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q7Z478 |
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| Residue: | 1369 |
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| Sequence: | MGGKNKKHKAPAAAVVRAAVSASRAKSAEAGIAGEAQSKKPVSRPATAAAAAAGSREPRV
KQGPKIYSFNSTNDSSGPANLDKSILKVVINNKLEQRIIGVINEHKKQNNDKGMISGRLT
AKKLQDLYMALQAFSFKTKDIEDAMTNTLLYGGDLHSALDWLCLNLSDDALPEGFSQEFE
EQQPKSRPKFQSPQIQATISPPLQPKTKTYEEDPKSKPKKEEKNMEVNMKEWILRYAEQQ
NEEEKNENSKSLEEEEKFDPNERYLHLAAKLLDAKEQAATFKLEKNKQGQKEAQEKIRKF
QREMETLEDHPVFNPAMKISHQQNERKKPPVATEGESALNFNLFEKSAAATEEEKDKKKE
PHDVRNFDYTARSWTGKSPKQFLIDWVRKNLPKSPNPSFEKVPVGRYWKCRVRVIKSEDD
VLVVCPTILTEDGMQAQHLGATLALYRLVKGQSVHQLLPPTYRDVWLEWSDAEKKREELN
KMETNKPRDLFIAKLLNKLKQQQQQQQQHSENKRENSEDPEESWENLVSDEDFSALSLES
ANVEDLEPVRNLFRKLQSTPKYQKLLKERQQLPVFKHRDSIVETLKRHRVVVVAGETGSG
KSTQVPHFLLEDLLLNEWEASKCNIVCTQPRRISAVSLANRVCDELGCENGPGGRNSLCG
YQIRMESRACESTRLLYCTTGVLLRKLQEDGLLSNVSHVIVDEVHERSVQSDFLLIILKE
ILQKRSDLHLILMSATVDSEKFSTYFTHCPILRISGRSYPVEVFHLEDIIEETGFVLEKD
SEYCQKFLEEEEEVTINVTSKAGGIKKYQEYIPVQTGAHADLNPFYQKYSSRTQHAILYM
NPHKINLDLILELLAYLDKSPQFRNIEGAVLIFLPGLAHIQQLYDLLSNDRRFYSERYKV
IALHSILSTQDQAAAFTLPPPGVRKIVLATNIAETGITIPDVVFVIDTGRTKENKYHESS
QMSSLVETFVSKASALQRQGRAGRVRDGFCFRMYTRERFEGFMDYSVPEILRVPLEELCL
HIMKCNLGSPEDFLSKALDPPQLQVISNAMNLLRKIGACELNEPKLTPLGQHLAALPVNV
KIGKMLIFGAIFGCLDPVATLAAVMTEKSPFTTPIGRKDEADLAKSALAMADSDHLTIYN
AYLGWKKARQEGGYRSEITYCRRNFLNRTSLLTLEDVKQELIKLVKAAGFSSSTTSTSWE
GNRASQTLSFQEIALLKAVLVAGLYDNVGKIIYTKSVDVTEKLACIVETAQGKAQVHPSS
VNRDLQTHGWLLYQEKIRYARVYLRETTLITPFPVLLFGGDIEVQHRERLLSIDGWIYFQ
APVKIAVIFKQLRVLIDSVLRKKLENPKMSLENDKILQIITELIKTENN
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| BDBM50239866 |
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| n/a |
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| Name | BDBM50239866 |
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| Synonyms: | CHEMBL4065018 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H23N3O3 |
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| Mol. Mass. | 437.4898 |
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| SMILES | O=C1Nc2cc(=O)n(Cc3ccccc3)cc2CN1c1cccc(OCc2ccccc2)c1 |
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| Structure | 
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