Reaction Details |
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Target | 72 kDa type IV collagenase |
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Ligand | BDBM50243038 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_1672495 |
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IC50 | 533±n/a nM |
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Citation | Tong, L; Kim, SH; Rosner, K; Yu, W; Shankar, BB; Chen, L; Li, D; Dai, C; Girijavallabhan, V; Popovici-Muller, J; Yang, L; Zhou, G; Kosinski, A; Siddiqui, MA; Shih, NY; Guo, Z; Orth, P; Chen, S; Lundell, D; Niu, X; Umland, S; Kozlowski, JA Fused bi-heteroaryl substituted hydantoin compounds as TACE inhibitors. Bioorg Med Chem Lett27:3037-3042 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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72 kDa type IV collagenase |
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Name: | 72 kDa type IV collagenase |
Synonyms: | 72 kDa gelatinase | 72 kDa type IV collagenase precursor | CLG4A | Gelatinase A | Gelatinase A (MMP-2) | MMP2 | MMP2_HUMAN | Matrix metalloproteinase-2 | Matrix metalloproteinase-2 (MMP 2) | Matrix metalloproteinase-2 (MMP2) | Matrix metalloproteinases 2 (MMP-2) | TBE-1 |
Type: | Enzyme |
Mol. Mass.: | 73870.36 |
Organism: | Homo sapiens (Human) |
Description: | P08253 |
Residue: | 660 |
Sequence: | MEALMARGALTGPLRALCLLGCLLSHAAAAPSPIIKFPGDVAPKTDKELAVQYLNTFYGC
PKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWD
KNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGD
GYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFN
GKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNAEGQPCKFPFRFQGT
SYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKY
ESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGAL
MAPIYTYTKNFRLSQDDIKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFDGIAQ
IRGEIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEY
WIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDP
GFPKLIADAWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC
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BDBM50243038 |
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n/a |
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Name | BDBM50243038 |
Synonyms: | CHEMBL4092752 |
Type | Small organic molecule |
Emp. Form. | C20H16N4O5 |
Mol. Mass. | 392.3648 |
SMILES | COc1ccc2CN(C[C@]3(NC(=O)NC3=O)c3cc4cnccc4o3)C(=O)c2c1 |r| |
Structure |
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