Ki Summary

Reaction Details

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Target

Gastrin/cholecystokinin type B receptor

Ligand

BDBM50003665

Substrate/Competitor

n/a

Meas. Tech.

ChEBML_47673

IC50

22±n/a nM

Citation

Tilley, JW; Danho, W; Madison, V; Fry, D; Swistok, J; Makofske, R; Michalewsky, J; Schwartz, A; Weatherford, S; Triscari, J Analogs of CCK incorporating conformationally constrained replacements for Asp32. J Med Chem35:4249-52 (1992) [PubMed]

More Info.:

Get all data from this article, Assay Method

Gastrin/cholecystokinin type B receptor

Name:

Gastrin/cholecystokinin type B receptor

Synonyms:

CCKBR | Cholecystokinin B receptor | GASR_BOVIN

Type:

PROTEIN

Mol. Mass.:

48807.54

Organism:

Bos taurus

Description:

ChEMBL_48437

Residue:

454

Sequence:

MELLKPNRSVLGSGPGPGASLCRSGGPLLNGSGTGNLSCEPPRIRGAGTRELELAIRVTL
YAVIFLMSVGGNVLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTF
IFGTVVCKAVSYFMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVATWM
LSGLLMVPYPVYTAVQPAGPRVLQCMHRWPSARVRQTWSVLLLLLLFFVPGVVMAVAYGL
ISRELYLGLRFDGDSDSESQSRVGSQGGLPGGTGQGPAQANGRCRSETRLAGEDGDGCYV
QLPRSRPALEMSALTAPTPGPGSGTRPAQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSAN
TWRAFDGPGAHRALSGAPISFIHLLTYASACVNPLVYCFMHRRFRQACLDTCTRCCPRPP
RARPRPLPDEDPPTPSIASLSRLSYTTISTLGPG

BDBM50003665

n/a

Name

BDBM50003665

Synonyms:

3-{2-[2-(2-{2-[2-Acetylamino-3-(4-sulfo-phenyl)-propionylamino]-4-methylsulfanyl-butyrylamino}-acetylamino)-3-(1H-indol-3-yl)-propionylamino]-4-methylsulfanyl-butyrylamino}-N-(1-carbamoyl-2-phenyl-ethyl)-succinamic acid | CHEMBL438911

Type

Small organic molecule

Emp. Form.

C47H59N9O13S3

Mol. Mass.

1054.219

SMILES

CSCC[C@H](NC(=O)[C@H](Cc1ccc(cc1)S(O)(=O)=O)NC(C)=O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O

Structure