| Reaction Details |
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 | Report a problem with these data |
| Target | Cholecystokinin receptor type A |
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| Ligand | BDBM50003668 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_49567 |
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| IC50 | 7400±n/a nM |
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| Citation |  Tilley, JW; Danho, W; Madison, V; Fry, D; Swistok, J; Makofske, R; Michalewsky, J; Schwartz, A; Weatherford, S; Triscari, J Analogs of CCK incorporating conformationally constrained replacements for Asp32. J Med Chem35:4249-52 (1992) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Cholecystokinin receptor type A |
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| Name: | Cholecystokinin receptor type A |
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| Synonyms: | CCK-A receptor | CCK-AR | CCK1-R | CCKAR | CCKAR_HUMAN | CCKRA | Cholecystokinin receptor | Cholecystokinin receptor type A | Cholecystokinin-1 Receptor |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 47859.34 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Stable expression of human CCK-1 receptors in HEK 293 cells. |
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| Residue: | 428 |
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| Sequence: | MDVVDSLLVNGSNITPPCELGLENETLFCLDQPRPSKEWQPAVQILLYSLIFLLSVLGNT
LVITVLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLKDFIFGSAVCKTTTYF
MGTSVSVSTFNLVAISLERYGAICKPLQSRVWQTKSHALKVIAATWCLSFTIMTPYPIYS
NLVPFTKNNNQTANMCRFLLPNDVMQQSWHTFLLLILFLIPGIVMMVAYGLISLELYQGI
KFEASQKKSAKERKPSTTSSGKYEDSDGCYLQKTRPPRKLELRQLSTGSSSRANRIRSNS
SAANLMAKKRVIRMLIVIVVLFFLCWMPIFSANAWRAYDTASAERRLSGTPISFILLLSY
TSSCVNPIIYCFMNKRFRLGFMATFPCCPNPGPPGARGEVGEEEEGGTTGASLSRFSYSH
MSASVPPQ
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| BDBM50003668 |
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| n/a |
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| Name | BDBM50003668 |
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| Synonyms: | CHEMBL3143146 | [1-[1-[4-(1-Carbamoyl-2-phenyl-ethylcarbamoyl)-5,5-dimethyl-thiazolidine-3-carbonyl]-5-(3-o-tolyl-ureido)-pentylcarbamoyl]-2-(1H-indol-3-yl)-ethyl]-carbamic acid tert-butyl ester |
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| Type | Small organic molecule |
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| Emp. Form. | C45H58N8O7S |
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| Mol. Mass. | 855.056 |
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| SMILES | Cc1ccccc1NC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C)C(=O)N1CSC(C)(C)[C@H]1C(=O)NC(Cc1ccccc1)C(N)=O |
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| Structure | 
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