Reaction Details |
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Target | Acyl-CoA (8-3)-desaturase |
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Ligand | BDBM50246045 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1676417 (CHEMBL4026560) |
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IC50 | 18±n/a nM |
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Citation | Fujimoto, J; Okamoto, R; Noguchi, N; Hara, R; Masada, S; Kawamoto, T; Nagase, H; Tamura, YO; Imanishi, M; Takagahara, S; Kubo, K; Tohyama, K; Iida, K; Andou, T; Miyahisa, I; Matsui, J; Hayashi, R; Maekawa, T; Matsunaga, N Discovery of 3,5-Diphenyl-4-methyl-1,3-oxazolidin-2-ones as Novel, Potent, and Orally Available?-5 Desaturase (D5D) Inhibitors. J Med Chem60:8963-8981 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Acyl-CoA (8-3)-desaturase |
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Name: | Acyl-CoA (8-3)-desaturase |
Synonyms: | FADS1 | FADS1_HUMAN | FADSD5 | Fatty acid desaturase 1 |
Type: | PROTEIN |
Mol. Mass.: | 51985.80 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1513296 |
Residue: | 444 |
Sequence: | MAPDPVAAETAAQGPTPRYFTWDEVAQRSGCEERWLVIDRKVYNISEFTRRHPGGSRVIS
HYAGQDATDPFVAFHINKGLVKKYMNSLLIGELSPEQPSFEPTKNKELTDEFRELRATVE
RMGLMKANHVFFLLYLLHILLLDGAAWLTLWVFGTSFLPFLLCAVLLSAVQAQAGWLQHD
FGHLSVFSTSKWNHLLHHFVIGHLKGAPASWWNHMHFQHHAKPNCFRKDPDINMHPFFFA
LGKILSVELGKQKKKYMPYNHQHKYFFLIGPPALLPLYFQWYIFYFVIQRKKWVDLAWMI
TFYVRFFLTYVPLLGLKAFLGLFFIVRFLESNWFVWVTQMNHIPMHIDHDRNMDWVSTQL
QATCNVHKSAFNDWFSGHLNFQIEHHLFPTMPRHNYHKVAPLVQSLCAKHGIEYQSKPLL
SAFADIIHSLKESGQLWLDAYLHQ
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BDBM50246045 |
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n/a |
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Name | BDBM50246045 |
Synonyms: | CHEMBL4090490 |
Type | Small organic molecule |
Emp. Form. | C17H16FNO4 |
Mol. Mass. | 317.3116 |
SMILES | COc1ccc(OC)c(c1)N1CC(OC1=O)c1ccc(F)cc1 |
Structure |
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