Reaction Details |
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Target | Aldo-keto reductase family 1 member B1 |
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Ligand | BDBM50008457 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_31764 |
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IC50 | 50.0±n/a nM |
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Citation | Mylari, BL; Beyer, TA; Scott, PJ; Aldinger, CE; Dee, MF; Siegel, TW; Zembrowski, WJ Potent, orally active aldose reductase inhibitors related to zopolrestat: surrogates for benzothiazole side chain. J Med Chem35:457-65 (1992) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Aldo-keto reductase family 1 member B1 |
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Name: | Aldo-keto reductase family 1 member B1 |
Synonyms: | AKR1B1 | ALDR1 | ALDR_HUMAN | ALR2 | AR | Aldo-keto reductase family 1 member B1 (AKR1B1) | Aldose Reductase (ALR2) | Aldose reductase | Aldose reductase (AR) |
Type: | Protein |
Mol. Mass.: | 35855.50 |
Organism: | Homo sapiens (Human) |
Description: | P15121. 4LAU; 2IKI; 4LB4; 2FZD; 2FZ8; 1US0 |
Residue: | 316 |
Sequence: | MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQ
EKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGK
EFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKP
AVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAK
HNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCA
LLSCTSHKDYPFHEEF
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BDBM50008457 |
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n/a |
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Name | BDBM50008457 |
Synonyms: | CHEMBL140012 | {3-[(3-Chloro-phenylthiocarbamoyl)-methyl]-4-oxo-3,4-dihydro-phthalazin-1-yl}-acetic acid |
Type | Small organic molecule |
Emp. Form. | C18H14ClN3O3S |
Mol. Mass. | 387.84 |
SMILES | OC(=O)Cc1nn(CC(=S)Nc2cccc(Cl)c2)c(=O)c2ccccc12 |
Structure |
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