Reaction Details |
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Target | Cysteine protease |
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Ligand | BDBM50258524 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_1690561 |
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Ki | 7.2±n/a nM |
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Citation | Previti, S; Ettari, R; Cosconati, S; Amendola, G; Chouchene, K; Wagner, A; Hellmich, UA; Ulrich, K; Krauth-Siegel, RL; Wich, PR; Schmid, I; Schirmeister, T; Gut, J; Rosenthal, PJ; Grasso, S; Zappalą, M Development of Novel Peptide-Based Michael Acceptors Targeting Rhodesain and Falcipain-2 for the Treatment of Neglected Tropical Diseases (NTDs). J Med Chem60:6911-6923 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cysteine protease |
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Name: | Cysteine protease |
Synonyms: | Rhodesain |
Type: | PROTEIN |
Mol. Mass.: | 48425.78 |
Organism: | Trypanosoma brucei rhodesiense |
Description: | ChEMBL_619861 |
Residue: | 450 |
Sequence: | MPRTEMVRFVRLPVVLLAMAACLASVALGSLHVEESLEMRFAAFKKKYGKVYKDAKEEAF
RFRAFEENMEQAKIQAAANPYATFGVTPFSDMTREEFRARYRNGASYFAAAQKRLRKTVN
VTTGRAPAAVDWREKGAVTPVKDQGQCGSCWAFSTIGNIEGQWQVAGNPLVSLSEQMLVS
CDTIDFGCGGGLMDNAFNWIVNSNGGNVFTEASYPYVSGNGEQPQCQMNGHEIGAAITDH
VDLPQDEDAIAAYLAENGPLAIAVDATSFMDYNGGILTSCTSEQLDHGVLLVGYNDSSNP
PYWIIKNSWSNMWGEDGYIRIEKGTNQCLMNQAVSSAVVGGPTPPPPPPPPPSATFTQDF
CEGKGCTKGCSHATFPTGECVQTTGVGSVIATCGASNLTQIIYPLSRSCSGLSVPITVPL
DKCIPILIGSVEYHCSTNPPTKAARLVPHQ
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BDBM50258524 |
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n/a |
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Name | BDBM50258524 |
Synonyms: | CHEMBL4081250 |
Type | Small organic molecule |
Emp. Form. | C34H33N3O7S |
Mol. Mass. | 627.707 |
SMILES | [O-][N+](=O)c1ccc(COC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CCc2ccccc2)\C=C\S(=O)(=O)c2ccccc2)cc1 |r| |
Structure |
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