| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Epithelial discoidin domain-containing receptor 1 |
|---|
| Ligand | BDBM50260036 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1692346 (CHEMBL4042995) |
|---|
| IC50 | 191±n/a nM |
|---|
| Citation |  Wang, Z; Zhang, Y; Bartual, SG; Luo, J; Xu, T; Du, W; Xun, Q; Tu, Z; Brekken, RA; Ren, X; Bullock, AN; Liang, G; Lu, X; Ding, K Tetrahydroisoquinoline-7-carboxamide Derivatives as New Selective Discoidin Domain Receptor 1 (DDR1) Inhibitors. ACS Med Chem Lett8:327-332 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Epithelial discoidin domain-containing receptor 1 |
|---|
| Name: | Epithelial discoidin domain-containing receptor 1 |
|---|
| Synonyms: | CAK | DDR1 | DDR1_HUMAN | Discoidin domain receptor 1 (DDR1) | Discoidin domain-containing receptor 1 (DDR1) | Discoidin receptor tyrosine kinase | EDDR1 | Epithelial discoidin domain receptor 1 | Epithelial discoidin domain receptor 1 (DDR1) | Epithelial discoidin domain-containing receptor 1 | Epithelial discoidin domain-containing receptor 1 (DDR1) | HGK2 | Mammary carcinoma kinase 10 | NEP | NTRK4 | PTK3A | Protein-tyrosine kinase RTK 6 | RTK6 | TRKE | Tyrosine-protein kinase CAK |
|---|
| Type: | Tyrosine-protein kinase |
|---|
| Mol. Mass.: | 101130.02 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q08345 |
|---|
| Residue: | 913 |
|---|
| Sequence: | MGPEALSSLLLLLLVASGDADMKGHFDPAKCRYALGMQDRTIPDSDISASSSWSDSTAAR
HSRLESSDGDGAWCPAGSVFPKEEEYLQVDLQRLHLVALVGTQGRHAGGLGKEFSRSYRL
RYSRDGRRWMGWKDRWGQEVISGNEDPEGVVLKDLGPPMVARLVRFYPRADRVMSVCLRV
ELYGCLWRDGLLSYTAPVGQTMYLSEAVYLNDSTYDGHTVGGLQYGGLGQLADGVVGLDD
FRKSQELRVWPGYDYVGWSNHSFSSGYVEMEFEFDRLRAFQAMQVHCNNMHTLGARLPGG
VECRFRRGPAMAWEGEPMRHNLGGNLGDPRARAVSVPLGGRVARFLQCRFLFAGPWLLFS
EISFISDVVNNSSPALGGTFPPAPWWPPGPPPTNFSSLELEPRGQQPVAKAEGSPTAILI
GCLVAIILLLLLIIALMLWRLHWRRLLSKAERRVLEEELTVHLSVPGDTILINNRPGPRE
PPPYQEPRPRGNPPHSAPCVPNGSALLLSNPAYRLLLATYARPPRGPGPPTPAWAKPTNT
QAYSGDYMEPEKPGAPLLPPPPQNSVPHYAEADIVTLQGVTGGNTYAVPALPPGAVGDGP
PRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPD
ATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLED
KAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTI
KIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLC
RAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQ
LHRFLAEDALNTV
|
|
|
|---|
| BDBM50260036 |
|---|
| n/a |
|---|
| Name | BDBM50260036 |
|---|
| Synonyms: | CHEMBL4085787 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H19F3N4O |
|---|
| Mol. Mass. | 412.4077 |
|---|
| SMILES | CC1CN(Cc2cc(ccc12)C(=O)Nc1cccc(c1)C(F)(F)F)c1cncnc1 |
|---|
| Structure | 
|
|---|
Search and Browse
