Reaction Details |
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Target | 26S proteasome non-ATPase regulatory subunit 14 |
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Ligand | BDBM50264555 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1698722 (CHEMBL4049704) |
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IC50 | 1100±n/a nM |
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Citation | Perez, C; Li, J; Parlati, F; Rouffet, M; Ma, Y; Mackinnon, AL; Chou, TF; Deshaies, RJ; Cohen, SM Discovery of an Inhibitor of the Proteasome Subunit Rpn11. J Med Chem60:1343-1361 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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26S proteasome non-ATPase regulatory subunit 14 |
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Name: | 26S proteasome non-ATPase regulatory subunit 14 |
Synonyms: | 26S Proteasome regulatory subunit Rpn11 (Rpn11) | POH1 | PSDE_HUMAN | PSMD14 | PSMD14 protein |
Type: | Protein |
Mol. Mass.: | 34576.68 |
Organism: | Homo sapiens (Human) |
Description: | O00487 |
Residue: | 310 |
Sequence: | MDRLLRLGGGMPGLGQGPPTDAPAVDTAEQVYISSLALLKMLKHGRAGVPMEVMGLMLGE
FVDDYTVRVIDVFAMPQSGTGVSVEAVDPVFQAKMLDMLKQTGRPEMVVGWYHSHPGFGC
WLSGVDINTQQSFEALSERAVAVVVDPIQSVKGKVVIDAFRLINANMMVLGHEPRQTTSN
LGHLNKPSIQALIHGLNRHYYSITINYRKNELEQKMLLNLHKKSWMEGLTLQDYSEHCKH
NESVVKEMLELAKNYNKAVEEEDKMTPEQLAIKNVGKQDPKRHLEEHVDVLMTSNIVQCL
AAMLDTVVFK
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BDBM50264555 |
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n/a |
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Name | BDBM50264555 |
Synonyms: | CHEMBL4093484 |
Type | Small organic molecule |
Emp. Form. | C20H12N2O4S2 |
Mol. Mass. | 408.45 |
SMILES | OC(=O)c1cnc2c(SSc3cccc4cc(cnc34)C(O)=O)cccc2c1 |
Structure |
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