| Reaction Details |
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 | Report a problem with these data |
| Target | Sphingosine kinase 1 |
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| Ligand | BDBM50266436 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1700849 (CHEMBL4051831) |
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| Ki | 5000±n/a nM |
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| Citation |  Childress, ES; Kharel, Y; Brown, AM; Bevan, DR; Lynch, KR; Santos, WL Transforming Sphingosine Kinase 1 Inhibitors into Dual and Sphingosine Kinase 2 Selective Inhibitors: Design, Synthesis, and in Vivo Activity. J Med Chem60:3933-3957 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sphingosine kinase 1 |
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| Name: | Sphingosine kinase 1 |
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| Synonyms: | SK1 | SPHK | SPHK1 | SPHK1_HUMAN | SPK | Sphingosine kinase 1 | Sphingosine kinase 1 (SPHK1) | Sphingosine kinase types 1 (SphK1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 42521.16 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NYA1 |
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| Residue: | 384 |
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| Sequence: | MDPAGGPRGVLPRPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEAEISFTLMLTERRNHA
RELVRSEELGRWDALVVMSGDGLMHEVVNGLMERPDWETAIQKPLCSLPAGSGNALAASL
NHYAGYEQVTNEDLLTNCTLLLCRRLLSPMNLLSLHTASGLRLFSVLSLAWGFIADVDLE
SEKYRRLGEMRFTLGTFLRLAALRTYRGRLAYLPVGRVGSKTPASPVVVQQGPVDAHLVP
LEEPVPSHWTVVPDEDFVLVLALLHSHLGSEMFAAPMGRCAAGVMHLFYVRAGVSRAMLL
RLFLAMEKGRHMEYECPYLVYVPVVAFRLEPKDGKGVFAVDGELMVSEAVQGQVHPNYFW
MVSGCVEPPPSWKPQQMPPPEEPL
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| BDBM50266436 |
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| n/a |
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| Name | BDBM50266436 |
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| Synonyms: | CHEMBL4093841 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H23ClF3N7O2S |
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| Mol. Mass. | 565.998 |
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| SMILES | Cl.[H][C@@]1(Cc2nc(no2)-c2ccc(Nc3nc(cs3)-c3ccc(OC(F)(F)F)cc3)cc2)CCCN1C(N)=N |r| |
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| Structure | 
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