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TargetLysyl oxidase homolog 2
LigandBDBM50266786
Substrate/Competitorn/a
Meas. Tech.ChEBML_1701368
IC50 120±n/a nM
Citation Rowbottom, MWBain, GCalderon, ILasof, TLonergan, DLai, AHuang, FDarlington, JProdanovich, PSantini, AMKing, CDGoulet, LShannon, KEMa, GLNguyen, KMacKenna, DAEvans, JFHutchinson, JH Identification of 4-(Aminomethyl)-6-(trifluoromethyl)-2-(phenoxy)pyridine Derivatives as Potent, Selective, and Orally Efficacious Inhibitors of the Copper-Dependent Amine Oxidase, Lysyl Oxidase-Like 2 (LOXL2). J Med Chem60:4403-4423 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Lysyl oxidase homolog 2
Name:Lysyl oxidase homolog 2
Synonyms:1.4.3.13 | LOXL2_RAT | Loxl2 | Lysyl oxidase homolog 2 | Lysyl oxidase-like protein 2
Type:PROTEIN
Mol. Mass.:87182.46
Organism:Rattus norvegicus
Description:ChEMBL_117513
Residue:776
Sequence:
MEIPFGSCLYSCLALLVLLPSLSLAQYESWPYQLQYPEYFQQPPPEHHQHQVPSDVVKIQ
VRLAGQKRKHNEGRVEVYYEGQWGTVCDDDFSIHAAHVVCREVGYVEAKSWTASSSYGPG
EGPIWLDNIYCTGKESTLAACSSNGWGVTDCKHPEDVGVVCSEKRIPGFKFDNSLINQIE
SLNIQVEDIRIRPILSAFRHRKPVTEGYVEVKEGKAWKQICDKHWTAKNSHVVCGMFGFP
AEKTYNPKAYKTFASRRKLRYWKFSMNCTGTEAHISSCKLGPPMFRDPVKNATCENGQPA
VVSCVPSQIFSPDGPSRFRKAYKPEQPLVRLRGGAQVGEGRVEVLKNGEWGTVCDDKWDL
VSASVVCRELGFGTAKEAVTGSRLGQGIGPIHLNEVQCTGTEKSIIDCKLNTESQGCNHE
EDAGVRCNIPIMGFQKKVRLNGGRNPYEGRVEVLTERNGSLVWGNVCGQNWGIVEAMVVC
RQLGLGFASNAFQETWYWHGNIFANKVIMSGVKCSGTELSLAHCRHDEEVVCPEGGVQYG
AGVACSETAPDLVLNAEIVQQTAYLEDRPMALLQCAMEENCLSASAVHTDPTRGHRRLLR
FSSQIHNNGQSDFRPKNGRHAWIWHDCHRHYHSMEVFTYYDLLSLNGTKVAEGHKASFCL
EDTECEGDIQKSYECANFGEQGITMGCWDMYRHDIDCQWIDITDVPPGDYLFQVVINPNY
EVPESDFSNNIMKCRSRYDGYRIWMYNCHVGGAFSEETEQKFEHFSGLLNNQLSVQ
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50266786
n/a
NameBDBM50266786
Synonyms:CHEMBL4063337
TypeSmall organic molecule
Emp. Form.C17H19ClFN3O3
Mol. Mass.367.802
SMILESCl.NCc1ccnc(Oc2cccc(c2)C(=O)N2C[C@@H](O)[C@H](F)C2)c1 |r|
Structure
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