Reaction Details |
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Target | Lysyl oxidase homolog 2 |
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Ligand | BDBM50266786 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_1701368 |
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IC50 | 120±n/a nM |
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Citation | Rowbottom, MW; Bain, G; Calderon, I; Lasof, T; Lonergan, D; Lai, A; Huang, F; Darlington, J; Prodanovich, P; Santini, AM; King, CD; Goulet, L; Shannon, KE; Ma, GL; Nguyen, K; MacKenna, DA; Evans, JF; Hutchinson, JH Identification of 4-(Aminomethyl)-6-(trifluoromethyl)-2-(phenoxy)pyridine Derivatives as Potent, Selective, and Orally Efficacious Inhibitors of the Copper-Dependent Amine Oxidase, Lysyl Oxidase-Like 2 (LOXL2). J Med Chem60:4403-4423 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Lysyl oxidase homolog 2 |
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Name: | Lysyl oxidase homolog 2 |
Synonyms: | 1.4.3.13 | LOXL2_RAT | Loxl2 | Lysyl oxidase homolog 2 | Lysyl oxidase-like protein 2 |
Type: | PROTEIN |
Mol. Mass.: | 87182.46 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_117513 |
Residue: | 776 |
Sequence: | MEIPFGSCLYSCLALLVLLPSLSLAQYESWPYQLQYPEYFQQPPPEHHQHQVPSDVVKIQ
VRLAGQKRKHNEGRVEVYYEGQWGTVCDDDFSIHAAHVVCREVGYVEAKSWTASSSYGPG
EGPIWLDNIYCTGKESTLAACSSNGWGVTDCKHPEDVGVVCSEKRIPGFKFDNSLINQIE
SLNIQVEDIRIRPILSAFRHRKPVTEGYVEVKEGKAWKQICDKHWTAKNSHVVCGMFGFP
AEKTYNPKAYKTFASRRKLRYWKFSMNCTGTEAHISSCKLGPPMFRDPVKNATCENGQPA
VVSCVPSQIFSPDGPSRFRKAYKPEQPLVRLRGGAQVGEGRVEVLKNGEWGTVCDDKWDL
VSASVVCRELGFGTAKEAVTGSRLGQGIGPIHLNEVQCTGTEKSIIDCKLNTESQGCNHE
EDAGVRCNIPIMGFQKKVRLNGGRNPYEGRVEVLTERNGSLVWGNVCGQNWGIVEAMVVC
RQLGLGFASNAFQETWYWHGNIFANKVIMSGVKCSGTELSLAHCRHDEEVVCPEGGVQYG
AGVACSETAPDLVLNAEIVQQTAYLEDRPMALLQCAMEENCLSASAVHTDPTRGHRRLLR
FSSQIHNNGQSDFRPKNGRHAWIWHDCHRHYHSMEVFTYYDLLSLNGTKVAEGHKASFCL
EDTECEGDIQKSYECANFGEQGITMGCWDMYRHDIDCQWIDITDVPPGDYLFQVVINPNY
EVPESDFSNNIMKCRSRYDGYRIWMYNCHVGGAFSEETEQKFEHFSGLLNNQLSVQ
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BDBM50266786 |
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n/a |
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Name | BDBM50266786 |
Synonyms: | CHEMBL4063337 |
Type | Small organic molecule |
Emp. Form. | C17H19ClFN3O3 |
Mol. Mass. | 367.802 |
SMILES | Cl.NCc1ccnc(Oc2cccc(c2)C(=O)N2C[C@@H](O)[C@H](F)C2)c1 |r| |
Structure |
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