| Reaction Details |
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 | Report a problem with these data |
| Target | STE20/SPS1-related proline-alanine-rich protein kinase |
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| Ligand | BDBM50267914 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1704121 (CHEMBL4055354) |
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| IC50 | 49000±n/a nM |
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| Citation |  Ishigami-Yuasa, M; Watanabe, Y; Mori, T; Masuno, H; Fujii, S; Kikuchi, E; Uchida, S; Kagechika, H Development of WNK signaling inhibitors as a new class of antihypertensive drugs. Bioorg Med Chem25:3845-3852 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| STE20/SPS1-related proline-alanine-rich protein kinase |
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| Name: | STE20/SPS1-related proline-alanine-rich protein kinase |
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| Synonyms: | 2.7.11.1 | PS/TK | PSTK1 | Pancreatic serine/threonine-protein kinase | Pask | STE20/SPS1-related proline-alanine-rich protein kinase | STK39_RAT | Serine/threonine-protein kinase 39 | Spak | Ste-20-related kinase | Stk39 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 60047.97 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_117413 |
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| Residue: | 553 |
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| Sequence: | MAEPSGSPVHVQLPQQAAPVTAAAAAPAAATSAPAPAPAPAAPAAPAPAPAAAPAPAPAA
QAVGWPICRDAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQ
AMSQCSHPNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIAT
ILKEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKT
FVGTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPP
TLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQKAKNREYLIEKLL
TRTPDIAQRAKKVRRVPGSSGHLHKTEDGDWEWSDDEMDEKSEEGKAAASQEKSRRVKEE
NPEISVNAGGIPEQIQSLSVHDSQGQPNANEDYREGPCAVNLVLRLRNSRKELNDIRFEF
TPGRDTADGVSQELFSAGLVDGHDVVIVAANLQKIVDDPKALKTLTFKLASGCDGAEIPD
EVKLIGFAQLSVS
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| BDBM50267914 |
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| n/a |
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| Name | BDBM50267914 |
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| Synonyms: | CHEMBL4067097 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H18ClN3O2 |
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| Mol. Mass. | 391.85 |
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| SMILES | CCOc1ccc2nc3cc(NC(=O)c4ccc(Cl)cc4)ccc3c(N)c2c1 |
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| Structure | 
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