| Reaction Details |
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 | Report a problem with these data |
| Target | Bromodomain-containing protein 9 |
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| Ligand | BDBM50269689 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1707030 (CHEMBL4058263) |
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| IC50 | 1500±n/a nM |
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| Citation |  Crawford, TD; Audia, JE; Bellon, S; Burdick, DJ; Bommi-Reddy, A; Côté, A; Cummings, RT; Duplessis, M; Flynn, EM; Hewitt, M; Huang, HR; Jayaram, H; Jiang, Y; Joshi, S; Kiefer, JR; Murray, J; Nasveschuk, CG; Neiss, A; Pardo, E; Romero, FA; Sandy, P; Sims, RJ; Tang, Y; Taylor, AM; Tsui, V; Wang, J; Wang, S; Wang, Y; Xu, Z; Zawadzke, L; Zhu, X; Albrecht, BK; Magnuson, SR; Cochran, AG GNE-886: A Potent and Selective Inhibitor of the Cat Eye Syndrome Chromosome Region Candidate 2 Bromodomain (CECR2). ACS Med Chem Lett8:737-741 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Bromodomain-containing protein 9 |
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| Name: | Bromodomain-containing protein 9 |
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| Synonyms: | BRD9 | BRD9_HUMAN | Bromodomain-containing protein 9 | Rhabdomyosarcoma antigen MU-RMS-40.8 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 66994.30 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_108000 |
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| Residue: | 597 |
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| Sequence: | MGKKHKKHKAEWRSSYEDYADKPLEKPLKLVLKVGGSEVTELSGSGHDSSYYDDRSDHER
ERHKEKKKKKKKKSEKEKHLDDEERRKRKEEKKRKREREHCDTEGEADDFDPGKKVEVEP
PPDRPVRACRTQPAENESTPIQQLLEHFLRQLQRKDPHGFFAFPVTDAIAPGYSMIIKHP
MDFGTMKDKIVANEYKSVTEFKADFKLMCDNAMTYNRPDTVYYKLAKKILHAGFKMMSKQ
AALLGNEDTAVEEPVPEVVPVQVETAKKSKKPSREVISCMFEPEGNACSLTDSTAEEHVL
ALVEHAADEARDRINRFLPGGKMGYLKRNGDGSLLYSVVNTAEPDADEEETHPVDLSSLS
SKLLPGFTTLGFKDERRNKVTFLSSATTALSMQNNSVFGDLKSDEMELLYSAYGDETGVQ
CALSLQEFVKDAGSYSKKVVDDLLDQITGGDHSRTLFQLKQRRNVPMKPPDEAKVGDTLG
DSSSSVLEFMSMKSYPDVSVDISMLSSLGKVKKELDPDDSHLNLDETTKLLQDLHEAQAE
RGGSRPSSNLSSLSNASERDQHHLGSPSRLSVGEQPDVTHDPYEFLQSPEPAASAKT
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| BDBM50269689 |
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| n/a |
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| Name | BDBM50269689 |
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| Synonyms: | CHEMBL4075584 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H27FN6O2 |
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| Mol. Mass. | 486.5407 |
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| SMILES | CN(C1CCN(CC1)c1cc(ncn1)-c1ccccc1F)C(=O)c1cn(CC=C)c(=O)c2[nH]ccc12 |
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| Structure | 
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