Reaction Details |
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Target | Protein arginine N-methyltransferase 5 |
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Ligand | BDBM50366992 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1735605 (CHEMBL4151141) |
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IC50 | 25±n/a nM |
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Citation | Bonday, ZQ; Cortez, GS; Grogan, MJ; Antonysamy, S; Weichert, K; Bocchinfuso, WP; Li, F; Kennedy, S; Li, B; Mader, MM; Arrowsmith, CH; Brown, PJ; Eram, MS; Szewczyk, MM; Barsyte-Lovejoy, D; Vedadi, M; Guccione, E; Campbell, RM LLY-283, a Potent and Selective Inhibitor of Arginine Methyltransferase 5, PRMT5, with Antitumor Activity. ACS Med Chem Lett9:612-617 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Protein arginine N-methyltransferase 5 |
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Name: | Protein arginine N-methyltransferase 5 |
Synonyms: | 72 kDa ICln-binding protein | ANM5_HUMAN | HRMT1L5 | Histone-arginine N-methyltransferase PRMT5 | IBP72 | JBP1 | Jak-binding protein 1 | PRMT5 | PRMT5/MEP50 complex | Protein arginine N-methyltransferase 5 (PRMT5) | Protein arginine methyltransferase 5 (PRMT5) | SKB1 | SKB1 homolog | SKB1Hs | Shk1 kinase-binding protein 1 homolog |
Type: | Enzyme |
Mol. Mass.: | 72679.99 |
Organism: | Homo sapiens (Human) |
Description: | O14744 |
Residue: | 637 |
Sequence: | MAAMAVGGAGGSRVSSGRDLNCVPEIADTLGAVAKQGFDFLCMPVFHPRFKREFIQEPAK
NRPGPQTRSDLLLSGRDWNTLIVGKLSPWIRPDSKVEKIRRNSEAAMLQELNFGAYLGLP
AFLLPLNQEDNTNLARVLTNHIHTGHHSSMFWMRVPLVAPEDLRDDIIENAPTTHTEEYS
GEEKTWMWWHNFRTLCDYSKRIAVALEIGADLPSNHVIDRWLGEPIKAAILPTSIFLTNK
KGFPVLSKMHQRLIFRLLKLEVQFIITGTNHHSEKEFCSYLQYLEYLSQNRPPPNAYELF
AKGYEDYLQSPLQPLMDNLESQTYEVFEKDPIKYSQYQQAIYKCLLDRVPEEEKDTNVQV
LMVLGAGRGPLVNASLRAAKQADRRIKLYAVEKNPNAVVTLENWQFEEWGSQVTVVSSDM
REWVAPEKADIIVSELLGSFADNELSPECLDGAQHFLKDDGVSIPGEYTSFLAPISSSKL
YNEVRACREKDRDPEAQFEMPYVVRLHNFHQLSAPQPCFTFSHPNRDPMIDNNRYCTLEF
PVEVNTVLHGFAGYFETVLYQDITLSIRPETHSPGMFSWFPILFPIKQPITVREGQTICV
RFWRCSNSKKVWYEWAVTAPVCSAIHNPTGRSYTIGL
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BDBM50366992 |
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n/a |
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Name | BDBM50366992 |
Synonyms: | CHEMBL4168754 |
Type | Small organic molecule |
Emp. Form. | C17H18N4O4 |
Mol. Mass. | 342.3492 |
SMILES | [H][C@@]1(O[C@H]([C@H](O)[C@@H]1O)n1ccc2c(N)ncnc12)[C@H](O)c1ccccc1 |r| |
Structure |
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