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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Cyclin-A2/Cyclin-dependent kinase 2 | ||
| Ligand | BDBM50368876 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1736240 (CHEMBL4151776) | ||
| IC50 | 38±n/a nM | ||
| Citation |  Hazlitt, RA; Teitz, T; Bonga, JD; Fang, J; Diao, S; Iconaru, L; Yang, L; Goktug, AN; Currier, DG; Chen, T; Rankovic, Z; Min, J; Zuo, J Development of Second-Generation CDK2 Inhibitors for the Prevention of Cisplatin-Induced Hearing Loss. J Med Chem61:7700-7709 (2018) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Cyclin-A2/Cyclin-dependent kinase 2 | |||
| Name: | Cyclin-A2/Cyclin-dependent kinase 2 | ||
| Synonyms: | CDK2-CyclinA | CDK2/A | CDK2/Cyclin A | CDK2/Cyclin A2 | Cyclin A2/dependent kinase 2 | Cyclin-Dependent Kinase 2 (CDK2) | Cyclin-Dependent Kinase 2 (CDK2A) | ||
| Type: | Protein Complex | ||
| Mol. Mass.: | n/a | ||
| Description: | Cdk2/Cyclin A kinase was purified from insect cells coinfected with Cyclin A/Cdk2 baculovirus. | ||
| Components: | This complex has 2 components. | ||
| Component 1 | |||
| Name: | Cyclin-dependent kinase 2 | ||
| Synonyms: | CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase | ||
| Type: | Enzyme Subunit | ||
| Mol. Mass.: | 33938.17 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P24941 | ||
| Residue: | 298 | ||
| Sequence: |
| ||
| Component 2 | |||
| Name: | Cyclin-A2 | ||
| Synonyms: | CCN1 | CCNA | CCNA1 | CCNA2 | CCNA2_HUMAN | Cyclin A | Cyclin-A | ||
| Type: | Enzyme Subunit | ||
| Mol. Mass.: | 48550.19 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P20248 | ||
| Residue: | 432 | ||
| Sequence: |
| ||
| BDBM50368876 | |||
| n/a | |||
| Name | BDBM50368876 | ||
| Synonyms: | CHEMBL507167 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C17H19F2N5O2 | ||
| Mol. Mass. | 363.3619 | ||
| SMILES | N[C@H]1CC[C@@H](CC1)NC(=O)c1n[nH]cc1NC(=O)c1c(F)cccc1F |r,wU:1.0,wD:4.7,(46.13,-48.47,;45.35,-47.14,;43.81,-47.15,;43.04,-45.82,;43.8,-44.49,;45.33,-44.47,;46.11,-45.8,;43.02,-43.17,;41.48,-43.18,;40.69,-41.85,;40.72,-44.52,;41.64,-45.77,;40.73,-47.03,;39.26,-46.56,;39.25,-45.01,;38,-44.11,;36.45,-44.1,;35.69,-42.77,;35.68,-45.44,;36.44,-46.76,;37.98,-46.76,;35.68,-48.09,;34.13,-48.09,;33.36,-46.75,;34.14,-45.42,;33.38,-44.08,)| | ||
| Structure | 
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