| Reaction Details |
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 | Report a problem with these data |
| Target | P2X purinoceptor 3 |
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| Ligand | BDBM50370297 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1737473 (CHEMBL4153223) |
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| IC50 | 500±n/a nM |
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| Citation |  Kwak, SH; Shin, S; Lee, JH; Shim, JK; Kim, M; Lee, SD; Lee, A; Bae, J; Park, JH; Abdelrahman, A; Müller, CE; Cho, SK; Kang, SG; Bae, MA; Yang, JY; Ko, H; Goddard, WA; Kim, YC Synthesis and structure-activity relationships of quinolinone and quinoline-based P2X7 receptor antagonists and their anti-sphere formation activities in glioblastoma cells. Eur J Med Chem151:462-481 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| P2X purinoceptor 3 |
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| Name: | P2X purinoceptor 3 |
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| Synonyms: | ATP receptor | P2RX3_RAT | P2X purinoceptor 3 | P2X3 | P2rx3 | Purinergic receptor | ratp2x3 | ratp2x3 + rsa |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 44397.63 |
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| Organism: | RAT |
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| Description: | Purinergic, P2X3 0 RAT::P49654 |
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| Residue: | 397 |
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| Sequence: | MNCISDFFTYETTKSVVVKSWTIGIINRAVQLLIISYFVGWVFLHEKAYQVRDTAIESSV
VTKVKGFGRYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPENEEKYRCVSDS
QCGPERFPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVEMPIMMEAENFTIFIKNSIR
FPLFNFEKGNLLPNLTDKDIKRCRFHPEKAPFCPILRVGDVVKFAGQDFAKLARTGGVLG
IKIGWVCDLDKAWDQCIPKYSFTRLDGVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKA
FGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADHYKARKFEE
VTETTLKGTASTNPVFASDQATVEKQSTDSGAYSIGH
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| BDBM50370297 |
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| n/a |
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| Name | BDBM50370297 |
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| Synonyms: | CHEMBL4160315 |
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| Type | Small organic molecule |
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| Emp. Form. | C41H28N6Na4O17S4 |
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| Mol. Mass. | 1096.91 |
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| SMILES | [Na;v0+].[Na;v0+].[Na;v0+].[Na;v0+].[#8-]S(=O)(=O)c1ccc(-[#7]-[#6](=O)-c2cc(-[#7]-[#6](=O)-[#7]-c3cc(cc(c3)-[#6](=O)-[#7]-c3ccc(cc3)S([#8-])(=O)=O)-[#6](=O)-[#7]-c3ccc(cc3)S([#8-])(=O)=O)cc(c2)-[#6](=O)-[#7]-c2ccc(cc2)S([#8-])(=O)=O)cc1 |
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| Structure | 
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