Reaction Details |
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Target | P2X purinoceptor 7 |
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Ligand | BDBM50370312 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1737459 (CHEMBL4153209) |
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IC50 | 120±n/a nM |
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Citation | Kwak, SH; Shin, S; Lee, JH; Shim, JK; Kim, M; Lee, SD; Lee, A; Bae, J; Park, JH; Abdelrahman, A; Müller, CE; Cho, SK; Kang, SG; Bae, MA; Yang, JY; Ko, H; Goddard, WA; Kim, YC Synthesis and structure-activity relationships of quinolinone and quinoline-based P2X7 receptor antagonists and their anti-sphere formation activities in glioblastoma cells. Eur J Med Chem151:462-481 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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P2X purinoceptor 7 |
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Name: | P2X purinoceptor 7 |
Synonyms: | ATP receptor | P2RX7 | P2RX7_HUMAN | P2X purinoceptor 7 (P2RX7) | P2X purinoceptor 7 (P2X7) | P2X7 | P2Z receptor | Purinergic receptor |
Type: | Protein |
Mol. Mass.: | 68602.85 |
Organism: | Homo sapiens (Human) |
Description: | Q99572 |
Residue: | 595 |
Sequence: | MPACCSCSDVFQYETNKVTRIQSMNYGTIKWFFHVIIFSYVCFALVSDKLYQRKEPVISS
VHTKVKGIAEVKEEIVENGVKKLVHSVFDTADYTFPLQGNSFFVMTNFLKTEGQEQRLCP
EYPTRRTLCSSDRGCKKGWMDPQSKGIQTGRCVVYEGNQKTCEVSAWCPIEAVEEAPRPA
LLNSAENFTVLIKNNIDFPGHNYTTRNILPGLNITCTFHKTQNPQCPIFRLGDIFRETGD
NFSDVAIQGGIMGIEIYWDCNLDRWFHHCRPKYSFRRLDDKTTNVSLYPGYNFRYAKYYK
ENNVEKRTLIKVFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLAAVFIDFLIDTYSS
NCCRSHIYPWCKCCQPCVVNEYYYRKKCESIVEPKPTLKYVSFVDESHIRMVNQQLLGRS
LQDVKGQEVPRPAMDFTDLSRLPLALHDTPPIPGQPEEIQLLRKEATPRSRDSPVWCQCG
SCLPSQLPESHRCLEELCCRKKPGACITTSELFRKLVLSRHVLQFLLLYQEPLLALDVDS
TNSRLRHCAYRCYATWRFGSQDMADFAILPSCCRWRIRKEFPKSEGQYSGFKSPY
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BDBM50370312 |
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n/a |
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Name | BDBM50370312 |
Synonyms: | CHEMBL4163482 |
Type | Small organic molecule |
Emp. Form. | C30H32N2O5 |
Mol. Mass. | 500.5855 |
SMILES | COC(=O)c1cc2c(NC(=O)C34CC5CC(CC(C5)C3)C4)cccc2n(Cc2ccc(OC)cc2)c1=O |THB:16:15:12:18.17.19,16:17:14.15.20:12,19:17:14:20.11.12,19:11:14:18.16.17| |
Structure |
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