| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Nitric oxide synthase, inducible |
|---|
| Ligand | BDBM50403471 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1738190 (CHEMBL4153940) |
|---|
| IC50 | >10000±n/a nM |
|---|
| Citation |  Maccallini, C; Di Matteo, M; Gallorini, M; Montagnani, M; Graziani, V; Ammazzalorso, A; Amoia, P; De Filippis, B; Di Silvestre, S; Fantacuzzi, M; Giampietro, L; Potenza, MA; Re, N; Pandolfi, A; Cataldi, A; Amoroso, R Discovery of N-{3-[(ethanimidoylamino)methyl]benzyl}-l-prolinamide dihydrochloride: A new potent and selective inhibitor of the inducible nitric oxide synthase as a promising agent for the therapy of malignant glioma. Eur J Med Chem152:53-64 (2018) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Nitric oxide synthase, inducible |
|---|
| Name: | Nitric oxide synthase, inducible |
|---|
| Synonyms: | Inducible NO synthase | Inducible NOS | Inducible nitric oxide synthase (iNOS) | Inosl | MAC-NOS | Macrophage NOS | NOS type II | NOS2_MOUSE | Nitric Oxide Synthase, inducible | Nitric oxide synthase, inducible (iNOS) | Nos2 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 130595.79 |
|---|
| Organism: | Mus musculus (mouse) |
|---|
| Description: | Recombinant enzyme overexpressed in E. coli. |
|---|
| Residue: | 1144 |
|---|
| Sequence: | MACPWKFLFKVKSYQSDLKEEKDINNNVKKTPCAVLSPTIQDDPKSHQNGSPQLLTGTAQ
NVPESLDKLHVTSTRPQYVRIKNWGSGEILHDTLHHKATSDFTCKSKSCLGSIMNPKSLT
RGPRDKPTPLEELLPHAIEFINQYYGSFKEAKIEEHLARLEAVTKEIETTGTYQLTLDEL
IFATKMAWRNAPRCIGRIQWSNLQVFDARNCSTAQEMFQHICRHILYATNNGNIRSAITV
FPQRSDGKHDFRLWNSQLIRYAGYQMPDGTIRGDAATLEFTQLCIDLGWKPRYGRFDVLP
LVLQADGQDPEVFEIPPDLVLEVTMEHPKYEWFQELGLKWYALPAVANMLLEVGGLEFPA
CPFNGWYMGTEIGVRDFCDTQRYNILEEVGRRMGLETHTLASLWKDRAVTEINVAVLHSF
QKQNVTIMDHHTASESFMKHMQNEYRARGGCPADWIWLVPPVSGSITPVFHQEMLNYVLS
PFYYYQIEPWKTHIWQNEKLRPRRREIRFRVLVKVVFFASMLMRKVMASRVRATVLFATE
TGKSEALARDLATLFSYAFNTKVVCMDQYKASTLEEEQLLLVVTSTFGNGDCPSNGQTLK
KSLFMLRELNHTFRYAVFGLGSSMYPQFCAFAHDIDQKLSHLGASQLAPTGEGDELSGQE
DAFRSWAVQTFRAACETFDVRSKHHIQIPKRFTSNATWEPQQYRLIQSPEPLDLNRALSS
IHAKNVFTMRLKSQQNLQSEKSSRTTLLVQLTFEGSRGPSYLPGEHLGIFPGNQTALVQG
ILERVVDCPTPHQTVCLEVLDESGSYWVKDKRLPPCSLSQALTYFLDITTPPTQLQLHKL
ARFATDETDRQRLEALCQPSEYNDWKFSNNPTFLEVLEEFPSLHVPAAFLLSQLPILKPR
YYSISSSQDHTPSEVHLTVAVVTYRTRDGQGPLHHGVCSTWIRNLKPQDPVPCFVRSVSG
FQLPEDPSQPCILIGPGTGIAPFRSFWQQRLHDSQHKGLKGGRMSLVFGCRHPEEDHLYQ
EEMQEMVRKRVLFQVHTGYSRLPGKPKVYVQDILQKQLANEVLSVLHGEQGHLYICGDVR
MARDVATTLKKLVATKLNLSEEQVEDYFFQLKSQKRYHEDIFGAVFSYGAKKGSALEEPK
ATRL
|
|
|
|---|
| BDBM50403471 |
|---|
| n/a |
|---|
| Name | BDBM50403471 |
|---|
| Synonyms: | CHEMBL4161080 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H26Cl2N4O |
|---|
| Mol. Mass. | 349.299 |
|---|
| SMILES | Cl.Cl.CC(C)[C@H](N)C(=O)NCc1cccc(CNC(C)=N)c1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
