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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Cell division cycle 7-related protein kinase/Protein DBF4 homolog A | ||
| Ligand | BDBM50450842 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1743829 (CHEMBL4178339) | ||
| IC50 | 1.2±n/a nM | ||
| Citation |  Kurasawa, O; Oguro, Y; Miyazaki, T; Homma, M; Mori, K; Iwai, K; Hara, H; Skene, R; Hoffman, I; Ohashi, A; Yoshida, S; Ishikawa, T; Cho, N Identification of a new class of potent Cdc7 inhibitors designed by putative pharmacophore model: Synthesis and biological evaluation of 2,3-dihydrothieno[3,2-d]pyrimidin-4(1H)-ones. Bioorg Med Chem25:2133-2147 (2017) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Cell division cycle 7-related protein kinase/Protein DBF4 homolog A | |||
| Name: | Cell division cycle 7-related protein kinase/Protein DBF4 homolog A | ||
| Synonyms: | Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase | CDC7 and DBF4 | CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase) | ||
| Type: | Protein | ||
| Mol. Mass.: | n/a | ||
| Description: | n/a | ||
| Components: | This complex has 2 components. | ||
| Component 1 | |||
| Name: | Protein DBF4 homolog A | ||
| Synonyms: | ASK | Activator of S phase kinase | Chiffon homolog A | DBF4 | DBF4-type zinc finger-containing protein 1 | DBF4A | DBF4A_HUMAN | Protein DBF4 homolog A | ZDBF1 | ||
| Type: | Regulatory subunit | ||
| Mol. Mass.: | 76869.65 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | n/a | ||
| Residue: | 674 | ||
| Sequence: |
| ||
| Component 2 | |||
| Name: | Cell division cycle 7-related protein kinase | ||
| Synonyms: | CDC7 | CDC7-related kinase | CDC7L1 | CDC7_HUMAN | Cell division cycle 7-related protein kinase (CDC7) | HsCdc7 | huCdc7 | ||
| Type: | Protein | ||
| Mol. Mass.: | 63908.16 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | O00311 | ||
| Residue: | 574 | ||
| Sequence: |
| ||
| BDBM50450842 | |||
| n/a | |||
| Name | BDBM50450842 | ||
| Synonyms: | CHEMBL4213805 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H21FN4O2S | ||
| Mol. Mass. | 412.48 | ||
| SMILES | Cc1n[nH]cc1-c1cc2N[C@]3(CC[C@](O)(CC3)c3ccc(F)cc3)NC(=O)c2s1 |r,wU:10.11,wD:13.18,(40.37,-51.96,;39.89,-50.5,;38.42,-50.02,;38.42,-48.48,;39.89,-48.01,;40.79,-49.25,;42.33,-49.24,;43.25,-50.5,;44.72,-50.02,;46.04,-50.78,;47.37,-50.02,;47.36,-51.56,;48.68,-52.33,;50.02,-51.57,;51.56,-51.57,;50.03,-50.03,;48.7,-49.25,;50.79,-52.9,;50.02,-54.23,;50.79,-55.57,;52.33,-55.57,;53.1,-56.89,;53.1,-54.22,;52.33,-52.9,;47.37,-48.48,;46.04,-47.7,;46.05,-46.16,;44.72,-48.47,;43.25,-48,)| | ||
| Structure | 
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