Ki Summary

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Target

Rho-associated protein kinase 1

Ligand

BDBM50450840

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1743831 (CHEMBL4178341)

IC50

130±n/a nM

Citation

Kurasawa, O; Oguro, Y; Miyazaki, T; Homma, M; Mori, K; Iwai, K; Hara, H; Skene, R; Hoffman, I; Ohashi, A; Yoshida, S; Ishikawa, T; Cho, N Identification of a new class of potent Cdc7 inhibitors designed by putative pharmacophore model: Synthesis and biological evaluation of 2,3-dihydrothieno[3,2-d]pyrimidin-4(1H)-ones. Bioorg Med Chem25:2133-2147 (2017) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Rho-associated protein kinase 1

Name:

Rho-associated protein kinase 1

Synonyms:

Type:

Serine/threonine-protein kinase

Mol. Mass.:

158156.77

Organism:

Homo sapiens (Human)

Description:

Q13464

Residue:

1354

Sequence:

MSTGDSFETRFEKMDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYK
DTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAF
FWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTA
EVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDY
ISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFP
DDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLS
SDIDTSNFDDLEEDKGEEETFPIPKAFVGNQLPFVGFTYYSNRRYLSSANPNDNRTSSNA
DKSLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLEST
VSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQLANEKL
SQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSISQLESLNRELQERNRILENSKSQTD
KDYYQLQAILEAERRDRGHDSEMIGDLQARITSLQEEVKHLKHNLEKVEGERKEAQDMLN
HSEKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMCEMEKKL
KEEREAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHLTGNKERMEDEVKNLTLQLEQES
NKRLLLQNELKTQAFEADNLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQYRGNEGQMR
ELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRENLKKIQELQNEKETLATQLDLAETKAE
SEQLARGLLEEQYFELTQESKKAASRNRQEITDKDHTVSRLEEANSMLTKDIEILRRENE
ELTEKMKKAEEEYKLEKEEEISNLKAAFEKNINTERTLKTQAVNKLAEIMNRKDFKIDRK
KANTQDLRKKEKENRKLQLELNQEREKFNQMVVKHQKELNDMQAQLVEECAHRNELQMQL
ASKESDIEQLRAKLLDLSDSTSVASFPSADETDGNLPESRIEGWLSVPNRGNIKRYGWKK
QYVVVSSKKILFYNDEQDKEQSNPSMVLDIDKLFHVRPVTQGDVYRAETEEIPKIFQILY
ANEGECRKDVEMEPVQQAEKTNFQNHKGHEFIPTLYHFPANCDACAKPLWHVFKPPPALE
CRRCHVKCHRDHLDKKEDLICPCKVSYDVTSARDMLLLACSQDEQKKWVTHLVKKIPKNP
PSGFVRASPRTLSTRSTANQSFRKVVKNTSGKTS

BDBM50450840

n/a

Name

BDBM50450840

Synonyms:

CHEMBL4204333

Type

Small organic molecule

Emp. Form.

C21H21FN4O2S

Mol. Mass.

412.48

SMILES

Cc1n[nH]cc1-c1cc2N[C@]3(CC[C@@](O)(CC3)c3ccc(F)cc3)NC(=O)c2s1 |r,wU:10.11,wD:13.14,(20.26,-53.26,;19.79,-51.8,;18.32,-51.32,;18.32,-49.78,;19.79,-49.31,;20.69,-50.55,;22.23,-50.54,;23.14,-51.8,;24.62,-51.32,;25.95,-52.08,;27.27,-51.32,;27.26,-52.86,;28.58,-53.63,;29.92,-52.87,;30.69,-54.2,;29.93,-51.33,;28.6,-50.55,;31.46,-52.87,;32.23,-54.2,;33.77,-54.21,;34.54,-52.87,;36.08,-52.87,;33.76,-51.53,;32.22,-51.54,;27.28,-49.78,;25.95,-49,;25.95,-47.46,;24.62,-49.77,;23.14,-49.29,)|

Structure