| Reaction Details |
|---|
 | Report a problem with these data |
| Target | High affinity choline transporter 1 |
|---|
| Ligand | BDBM50451447 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1745413 (CHEMBL4179923) |
|---|
| Ki | 68±n/a nM |
|---|
| Citation |  Storer, RI; Pike, A; Swain, NA; Alexandrou, AJ; Bechle, BM; Blakemore, DC; Brown, AD; Castle, NA; Corbett, MS; Flanagan, NJ; Fengas, D; Johnson, MS; Jones, LH; Marron, BE; Payne, CE; Printzenhoff, D; Rawson, DJ; Rose, CR; Ryckmans, T; Sun, J; Theile, JW; Torella, R; Tseng, E; Warmus, JS Highly potent and selective Na Bioorg Med Chem Lett27:4805-4811 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| High affinity choline transporter 1 |
|---|
| Name: | High affinity choline transporter 1 |
|---|
| Synonyms: | CHT1 | High-affinity choline transporter | SC5A7_HUMAN | SLC5A7 | high affinity choline transporter 1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 63194.33 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1464247 |
|---|
| Residue: | 580 |
|---|
| Sequence: | MAFHVEGLIAIIVFYLLILLVGIWAAWRTKNSGSAEERSEAIIVGGRDIGLLVGGFTMTA
TWVGGGYINGTAEAVYVPGYGLAWAQAPIGYSLSLILGGLFFAKPMRSKGYVTMLDPFQQ
IYGKRMGGLLFIPALMGEMFWAAAIFSALGATISVIIDVDMHISVIISALIATLYTLVGG
LYSVAYTDVVQLFCIFVGLWISVPFALSHPAVADIGFTAVHAKYQKPWLGTVDSSEVYSW
LDSFLLLMLGGIPWQAYFQRVLSSSSATYAQVLSFLAAFGCLVMAIPAILIGAIGASTDW
NQTAYGLPDPKTTEEADMILPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFA
RNIYQLSFRQNASDKEIVWVMRITVFVFGASATAMALLTKTVYGLWYLSSDLVYIVIFPQ
LLCVLFVKGTNTYGAVAGYVSGLFLRITGGEPYLYLQPLIFYPGYYPDDNGIYNQKFPFK
TLAMVTSFLTNICISYLAKYLFESGTLPPKLDVFDAVVARHSEENMDKTILVKNENIKLD
ELALVKPRQSMTLSSTFTNKEAFLDVDSSPEGSGTEDNLQ
|
|
|
|---|
| BDBM50451447 |
|---|
| n/a |
|---|
| Name | BDBM50451447 |
|---|
| Synonyms: | CHEMBL4217988 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C35H32F3N7O3S2 |
|---|
| Mol. Mass. | 719.799 |
|---|
| SMILES | FC(F)(F)c1cccc(c1)-c1ccc(Oc2ccc(cc2C#N)S(=O)(=O)Nc2ncns2)c(c1)-c1ccnc(CNCCC2CCNCC2)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
