| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 6 |
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| Ligand | BDBM50451679 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1746078 (CHEMBL4180588) |
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| IC50 | 1.6±n/a nM |
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| Citation |  Fu, Y; Tang, S; Su, Y; Lan, X; Ye, Y; Zha, C; Li, L; Cao, J; Chen, Y; Jiang, L; Huang, Y; Ding, J; Geng, M; Huang, M; Wan, H Discovery of a class of diheteroaromatic amines as orally bioavailable CDK1/4/6 inhibitors. Bioorg Med Chem Lett27:5332-5336 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 6 |
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| Name: | Cyclin-dependent kinase 6 |
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| Synonyms: | CDK6 | CDK6_HUMAN | CDKN6 | Cell division protein kinase 6 | Cyclin-dependent kinase 6 (CDK 6) | Serine/threonine-protein kinase PLSTIRE |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 36937.42 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q00534 |
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| Residue: | 326 |
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| Sequence: | MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIR
EVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTE
TIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVV
VTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGE
EDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF
QDLERCKENLDSHLPPSQNTSELNTA
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| BDBM50451679 |
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| n/a |
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| Name | BDBM50451679 |
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| Synonyms: | CHEMBL4214634 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H34FN9O |
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| Mol. Mass. | 519.617 |
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| SMILES | COCCN1CCN(Cc2cnc(Nc3cc(ncn3)-c3cc(F)c4nc(C)n(C(C)C)c4c3)cn2)CC1 |
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| Structure | 
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