Reaction Details |
| Report a problem with these data |
Target | cGMP-dependent 3',5'-cyclic phosphodiesterase |
---|
Ligand | BDBM50452207 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1747200 (CHEMBL4181710) |
---|
Ki | 10100±n/a nM |
---|
Citation | Forster, AB; Abeywickrema, P; Bunda, J; Cox, CD; Cabalu, TD; Egbertson, M; Fay, J; Getty, K; Hall, D; Kornienko, M; Lu, J; Parthasarathy, G; Reid, J; Sharma, S; Shipe, WD; Smith, SM; Soisson, S; Stachel, SJ; Su, HP; Wang, D; Berger, R The identification of a novel lead class for phosphodiesterase 2 inhibition by fragment-based drug design. Bioorg Med Chem Lett27:5167-5171 (2017) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
cGMP-dependent 3',5'-cyclic phosphodiesterase |
---|
Name: | cGMP-dependent 3',5'-cyclic phosphodiesterase |
Synonyms: | CGS-PDE | Cyclic GMP-stimulated phosphodiesterase | Homo sapiens phosphodiesterase 2A (PDE2A) | NM_002599 | PDE2A | PDE2A_HUMAN | cGSPDE |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 105691.58 |
Organism: | Homo sapiens (Human) |
Description: | O00408 |
Residue: | 941 |
Sequence: | MGQACGHSILCRSQQYPAARPAEPRGQQVFLKPDEPPPPPQPCADSLQDALLSLGSVIDI
SGLQRAVKEALSAVLPRVETVYTYLLDGESQLVCEDPPHELPQEGKVREAIISQKRLGCN
GLGFSDLPGKPLARLVAPLAPDTQVLVMPLADKEAGAVAAVILVHCGQLSDNEEWSLQAV
EKHTLVALRRVQVLQQRGPREAPRAVQNPPEGTAEDQKGGAAYTDRDRKILQLCGELYDL
DASSLQLKVLQYLQQETRASRCCLLLVSEDNLQLSCKVIGDKVLGEEVSFPLTGCLGQVV
EDKKSIQLKDLTSEDVQQLQSMLGCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTD
EDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITE
ARNLSNAEICSVFLLDQNELVAKVFDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPD
AYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAF
SIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNF
ASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMH
AFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYS
SEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDL
QKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAM
GNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSH
KFTIRGLPSNNSLDFLDEEYEVPDLDGTRAPINGCCSLDAE
|
|
|
BDBM50452207 |
---|
n/a |
---|
Name | BDBM50452207 |
Synonyms: | CHEMBL4207765 |
Type | Small organic molecule |
Emp. Form. | C15H13ClF3N5 |
Mol. Mass. | 355.745 |
SMILES | Cn1ncc2c(NCCc3ccc(cc3)C(F)(F)F)nc(Cl)nc12 |
Structure |
|