Reaction Details |
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Target | TGF-beta receptor type-1 |
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Ligand | BDBM412755 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1753651 (CHEMBL4188411) |
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IC50 | 1.000000±n/a nM |
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Citation | Harikrishnan, LS; Warrier, J; Tebben, AJ; Tonukunuru, G; Madduri, SR; Baligar, V; Mannoori, R; Seshadri, B; Rahaman, H; Arunachalam, PN; Dikundwar, AG; Fink, BE; Fargnoli, J; Fereshteh, M; Fan, Y; Lippy, J; Ho, CP; Wautlet, B; Sheriff, S; Ruzanov, M; Borzilleri, RM Heterobicyclic inhibitors of transforming growth factor beta receptor I (TGF?RI). Bioorg Med Chem26:1026-1034 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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TGF-beta receptor type-1 |
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Name: | TGF-beta receptor type-1 |
Synonyms: | ALK-5 | ALK5 | Activin A receptor type II-like protein kinase of 53kD | Activin receptor-like kinase 5 | SKR4 | Serine/threonine-protein kinase receptor R4 | TGF-beta receptor type I | TGF-beta type I receptor | TGFBR1 | TGFR-1 | TGFR1_HUMAN | TbetaR-I | Transforming growth factor-beta receptor type I |
Type: | enzyme |
Mol. Mass.: | 55968.24 |
Organism: | Homo sapiens (Human) |
Description: | P36897 |
Residue: | 503 |
Sequence: | MEAAVAAPRPRLLLLVLAAAAAAAAALLPGATALQCFCHLCTKDNFTCVTDGLCFVSVTE
TTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGSVTTTYCCNQDHCNKIELPTTVKSSPG
LGPVELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDL
IYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREER
SWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVE
GMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDS
ATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGI
HEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGA
ARLTALRIKKTLSQLSQQEGIKM
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BDBM412755 |
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n/a |
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Name | BDBM412755 |
Synonyms: | N-(4-((2-(6-(trifluoromethyl)pyridin-2-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)pyridin-2-yl)acetamide | US10399987, Example 20 |
Type | Small organic molecule |
Emp. Form. | C19H14F3N7O |
Mol. Mass. | 413.356 |
SMILES | CC(=O)Nc1cc(Nc2nc(nc3[nH]ccc23)-c2cccc(n2)C(F)(F)F)ccn1 |
Structure |
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