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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | TGF-beta receptor type-1 | ||
| Ligand | BDBM21509 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1753651 (CHEMBL4188411) | ||
| IC50 | 3.7±n/a nM | ||
| Citation |  Harikrishnan, LS; Warrier, J; Tebben, AJ; Tonukunuru, G; Madduri, SR; Baligar, V; Mannoori, R; Seshadri, B; Rahaman, H; Arunachalam, PN; Dikundwar, AG; Fink, BE; Fargnoli, J; Fereshteh, M; Fan, Y; Lippy, J; Ho, CP; Wautlet, B; Sheriff, S; Ruzanov, M; Borzilleri, RM Heterobicyclic inhibitors of transforming growth factor beta receptor I (TGF?RI). Bioorg Med Chem26:1026-1034 (2018) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| TGF-beta receptor type-1 | |||
| Name: | TGF-beta receptor type-1 | ||
| Synonyms: | ALK-5 | ALK5 | Activin A receptor type II-like protein kinase of 53kD | Activin receptor-like kinase 5 | SKR4 | Serine/threonine-protein kinase receptor R4 | TGF-beta receptor type I | TGF-beta type I receptor | TGFBR1 | TGFR-1 | TGFR1_HUMAN | TbetaR-I | Transforming growth factor-beta receptor type I | ||
| Type: | enzyme | ||
| Mol. Mass.: | 55968.24 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P36897 | ||
| Residue: | 503 | ||
| Sequence: |
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| BDBM21509 | |||
| n/a | |||
| Name | BDBM21509 | ||
| Synonyms: | 4-[2-({4-[2-(pyridin-2-yl)-4H,5H,6H-pyrrolo[1,2-a]pyrazol-3-yl]quinolin-7-yl}oxy)ethyl]morpholine | Dihydropyrrolopyrazole, 15d | ||
| Type | Small organic molecule | ||
| Emp. Form. | C26H27N5O2 | ||
| Mol. Mass. | 441.5249 | ||
| SMILES | C(CN1CCOCC1)Oc1ccc2c(ccnc2c1)-c1c2CCCn2nc1-c1ccccn1 |(-6.23,1.24,;-7.56,.47,;-7.56,-1.07,;-8.89,-1.84,;-8.89,-3.38,;-7.56,-4.15,;-6.23,-3.38,;-6.23,-1.84,;-6.23,2.78,;-4.89,3.55,;-4.89,5.09,;-3.56,5.86,;-2.22,5.09,;-.89,5.86,;.44,5.09,;.44,3.55,;-.89,2.78,;-2.22,3.55,;-3.56,2.78,;-.89,7.4,;-1.89,8.57,;-3.39,8.93,;-3.51,10.46,;-2.09,11.05,;-1.09,9.88,;.41,9.52,;.53,7.99,;1.84,7.18,;1.86,5.64,;3.21,4.89,;4.53,5.67,;4.51,7.21,;3.17,7.97,)| | ||
| Structure | 
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