Reaction Details | |||
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Target | TGF-beta receptor type-2 | ||
Ligand | BDBM50454873 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1753652 (CHEMBL4188412) | ||
IC50 | 2000±n/a nM | ||
Citation | Harikrishnan, LS; Warrier, J; Tebben, AJ; Tonukunuru, G; Madduri, SR; Baligar, V; Mannoori, R; Seshadri, B; Rahaman, H; Arunachalam, PN; Dikundwar, AG; Fink, BE; Fargnoli, J; Fereshteh, M; Fan, Y; Lippy, J; Ho, CP; Wautlet, B; Sheriff, S; Ruzanov, M; Borzilleri, RM Heterobicyclic inhibitors of transforming growth factor beta receptor I (TGF?RI). Bioorg Med Chem26:1026-1034 (2018) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
TGF-beta receptor type-2 | |||
Name: | TGF-beta receptor type-2 | ||
Synonyms: | TGF-beta receptor type II | TGFBR2 | TGFR2_HUMAN | ||
Type: | PROTEIN | ||
Mol. Mass.: | 64559.49 | ||
Organism: | Homo sapiens (Human) | ||
Description: | ChEMBL_586859 | ||
Residue: | 567 | ||
Sequence: |
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BDBM50454873 | |||
n/a | |||
Name | BDBM50454873 | ||
Synonyms: | CHEMBL4214470 | ||
Type | Small organic molecule | ||
Emp. Form. | C23H25FN8 | ||
Mol. Mass. | 432.4966 | ||
SMILES | N[C@H]1CC[C@H](CC1)NCc1ccn2nc(nc(Nc3ccncc3F)c12)-c1ccccn1 |r,wU:4.7,1.0,(39.54,-37.59,;39.55,-36.05,;38.23,-35.26,;38.24,-33.73,;39.58,-32.98,;40.91,-33.75,;40.89,-35.29,;39.6,-31.44,;38.27,-30.66,;38.28,-29.12,;39.68,-28.5,;39.52,-26.97,;38.01,-26.65,;37.24,-25.32,;35.69,-25.33,;34.93,-26.65,;35.7,-27.98,;34.93,-29.32,;33.38,-29.32,;32.61,-27.98,;31.06,-27.98,;30.29,-29.32,;31.07,-30.67,;32.61,-30.66,;33.39,-31.99,;37.25,-27.98,;34.92,-24,;33.38,-24,;32.59,-22.67,;33.37,-21.32,;34.91,-21.32,;35.69,-22.65,)| | ||
Structure |