Reaction Details |
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Target | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A |
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Ligand | BDBM50457949 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1761125 (CHEMBL4196372) |
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IC50 | 8100±n/a nM |
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Citation | Ch?o?-Rzepa, G; Jankowska, A; ?lusarczyk, M; ?wierczek, A; Pociecha, K; Wyska, E; Bucki, A; Gawalska, A; Ko?aczkowski, M; Paw?owski, M Novel butanehydrazide derivatives of purine-2,6-dione as dual PDE4/7 inhibitors with potential anti-inflammatory activity: Design, synthesis and biological evaluation. Eur J Med Chem146:381-394 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A |
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Name: | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A |
Synonyms: | 3',5'-cyclic phosphodiesterase | PDE7A | PDE7A_HUMAN | Phosphodiesterase 7 | Phosphodiesterase 7 (PDE7) | Phosphodiesterase 7A | Phosphodiesterase 7A (PDE7A1) |
Type: | Enzyme |
Mol. Mass.: | 55514.96 |
Organism: | Homo sapiens (Human) |
Description: | Q13946 |
Residue: | 482 |
Sequence: | MEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTA
LYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLRS
SRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSL
HGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPW
DILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESGLFS
HLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKC
ADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYL
VEPLFTEWARFSNTRLSQTMLGHVGLNKASWKGLQREQSSSEDTDAAFELNSQLLPQENR
LS
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BDBM50457949 |
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n/a |
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Name | BDBM50457949 |
Synonyms: | CHEMBL4205843 |
Type | Small organic molecule |
Emp. Form. | C25H27N7O6 |
Mol. Mass. | 521.5252 |
SMILES | Cn1c2nc(NCc3ccccc3)n(CCCC(=O)N\N=C\c3ccc(O)c(O)c3O)c2c(=O)n(C)c1=O |
Structure |
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