Reaction Details |
| Report a problem with these data |
Target | Proteasome subunit beta type-1 |
---|
Ligand | BDBM50069989 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1761588 (CHEMBL4196835) |
---|
IC50 | 700±n/a nM |
---|
Citation | Tanaka, M; Zhu, Y; Shionyu, M; Ota, N; Shibata, N; Watanabe, C; Mizusawa, A; Sasaki, R; Mizukami, T; Shiina, I; Hasegawa, M Ridaifen-F conjugated with cell-penetrating peptides inhibits intracellular proteasome activities and induces drug-resistant cell death. Eur J Med Chem146:636-650 (2018) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Proteasome subunit beta type-1 |
---|
Name: | Proteasome subunit beta type-1 |
Synonyms: | PSB1_HUMAN | PSC5 | PSMB1 | Proteasome component C5 | Proteasome subunit beta type-1/beta type-5 |
Type: | PROTEIN |
Mol. Mass.: | 26493.62 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1366691 |
Residue: | 241 |
Sequence: | MLSSTAMYSAPGRDLGMEPHRAAGPLQLRFSPYVFNGGTILAIAGEDFAIVASDTRLSEG
FSIHTRDSPKCYKLTDKTVIGCSGFHGDCLTLTKIIEARLKMYKHSNNKAMTTGAIAAML
STILYSRRFFPYYVYNIIGGLDEEGKGAVYSFDPVGSYQRDSFKAGGSASAMLQPLLDNQ
VGFKNMQNVEHVPLSLDRAMRLVKDVFISAAERDVYTGDALRICIVTKEGIREETVSLRK
D
|
|
|
BDBM50069989 |
---|
n/a |
---|
Name | BDBM50069989 |
Synonyms: | (R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butylboronic acid | (R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-6-carboxamido)propanamido)butylboronic acid | BORTEZOMIB | CHEMBL325041 | Dipeptidyl boronic acid derivative | LDP-341 | N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE | PS-341 | Peptidyl boronic acid derivative | US11542283, Compound Velcade | Velcade | cid_387447 |
Type | Small organic molecule |
Emp. Form. | C19H25BN4O4 |
Mol. Mass. | 384.237 |
SMILES | CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cnccn1)B(O)O |r| |
Structure |
|