Reaction Details |
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Target | Synaptic vesicular amine transporter |
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Ligand | BDBM50459628 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1766890 (CHEMBL4202137) |
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Ki | 6160±n/a nM |
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Citation | Provencher, BA; Eshleman, AJ; Johnson, RA; Shi, X; Kryatova, O; Nelson, J; Tian, J; Gonzalez, M; Meltzer, PC; Janowsky, A Synthesis and Discovery of Arylpiperidinylquinazolines: New Inhibitors of the Vesicular Monoamine Transporter. J Med Chem61:9121-9131 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Synaptic vesicular amine transporter |
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Name: | Synaptic vesicular amine transporter |
Synonyms: | Monoamine transporter | SLC18A2 | SVMT | Solute carrier family 18 member 2 | VAT2 | VMAT2 | VMAT2_HUMAN | Vesicular amine transporter 2 |
Type: | PROTEIN |
Mol. Mass.: | 55709.61 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_610810 |
Residue: | 514 |
Sequence: | MALSELALVRWLQESRRSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNATEI
QTARPVHTASISDSFQSIFSYYDNSTMVTGNATRDLTLHQTATQHMVTNASAVPSDCPSE
DKDLLNENVQVGLLFASKATVQLITNPFIGLLTNRIGYPIPIFAGFCIMFVSTIMFAFSS
SYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGNVMGIALGGLAMGVLVGPPFGS
VLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGS
ICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLC
ALLGMIIVGVSILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGS
VYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDILFAPLCFFLRSPPAKEEKM
AILMDHNCPIKTKMYTQNNIQSYPIGEDEESESD
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BDBM50459628 |
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n/a |
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Name | BDBM50459628 |
Synonyms: | CHEMBL4208250 |
Type | Small organic molecule |
Emp. Form. | C22H25N3O4S |
Mol. Mass. | 427.517 |
SMILES | CCOC(=O)[C@@H]1CN(CCn2c(=O)[nH]c3ccccc3c2=O)CC[C@@H]1c1cccs1 |r| |
Structure |
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