Reaction Details |
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Target | Synaptic vesicular amine transporter |
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Ligand | BDBM50192902 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1766890 (CHEMBL4202137) |
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Ki | 64±n/a nM |
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Citation | Provencher, BA; Eshleman, AJ; Johnson, RA; Shi, X; Kryatova, O; Nelson, J; Tian, J; Gonzalez, M; Meltzer, PC; Janowsky, A Synthesis and Discovery of Arylpiperidinylquinazolines: New Inhibitors of the Vesicular Monoamine Transporter. J Med Chem61:9121-9131 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Synaptic vesicular amine transporter |
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Name: | Synaptic vesicular amine transporter |
Synonyms: | Monoamine transporter | SLC18A2 | SVMT | Solute carrier family 18 member 2 | VAT2 | VMAT2 | VMAT2_HUMAN | Vesicular amine transporter 2 |
Type: | PROTEIN |
Mol. Mass.: | 55709.61 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_610810 |
Residue: | 514 |
Sequence: | MALSELALVRWLQESRRSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNATEI
QTARPVHTASISDSFQSIFSYYDNSTMVTGNATRDLTLHQTATQHMVTNASAVPSDCPSE
DKDLLNENVQVGLLFASKATVQLITNPFIGLLTNRIGYPIPIFAGFCIMFVSTIMFAFSS
SYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGNVMGIALGGLAMGVLVGPPFGS
VLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGS
ICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLC
ALLGMIIVGVSILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGS
VYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDILFAPLCFFLRSPPAKEEKM
AILMDHNCPIKTKMYTQNNIQSYPIGEDEESESD
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BDBM50192902 |
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n/a |
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Name | BDBM50192902 |
Synonyms: | 2-ethyl-3-isobutyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-2-ol | CHEMBL213814 | Ro-4-1284 |
Type | Small organic molecule |
Emp. Form. | C21H33NO3 |
Mol. Mass. | 347.4916 |
SMILES | CCC1(O)CC2N(CCc3cc(OC)c(OC)cc23)CC1CC(C)C |
Structure |
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