Ki Summary

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Target

Receptor tyrosine-protein kinase erbB-3

Ligand

BDBM50461175

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1770733 (CHEMBL4222845)

IC50

2.4±n/a nM

Citation

Hei, YY; Shen, Y; Wang, J; Zhang, H; Zhao, HY; Xin, M; Cao, YX; Li, Y; Zhang, SQ Synthesis and evaluation of 2,9-disubstituted 8-phenylthio/phenylsulfinyl-9H-purine as new EGFR inhibitors. Bioorg Med Chem26:2173-2185 (2018) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Receptor tyrosine-protein kinase erbB-3

Name:

Receptor tyrosine-protein kinase erbB-3

Synonyms:

ERBB3 | ERBB3_HUMAN | HER3 | Proto-oncogene-like protein c-ErbB-3 | Tyrosine kinase-type cell surface receptor HER3

Type:

PROTEIN

Mol. Mass.:

148097.73

Organism:

Homo sapiens (Human)

Description:

ChEMBL_774331

Residue:

1342

Sequence:

MRANDALQVLGLLFSLARGSEVGNSQAVCPGTLNGLSVTGDAENQYQTLYKLYERCEVVM
GNLEIVLTGHNADLSFLQWIREVTGYVLVAMNEFSTLPLPNLRVVRGTQVYDGKFAIFVM
LNYNTNSSHALRQLRLTQLTEILSGGVYIEKNDKLCHMDTIDWRDIVRDRDAEIVVKDNG
RSCPPCHEVCKGRCWGPGSEDCQTLTKTICAPQCNGHCFGPNPNQCCHDECAGGCSGPQD
TDCFACRHFNDSGACVPRCPQPLVYNKLTFQLEPNPHTKYQYGGVCVASCPHNFVVDQTS
CVRACPPDKMEVDKNGLKMCEPCGGLCPKACEGTGSGSRFQTVDSSNIDGFVNCTKILGN
LDFLITGLNGDPWHKIPALDPEKLNVFRTVREITGYLNIQSWPPHMHNFSVFSNLTTIGG
RSLYNRGFSLLIMKNLNVTSLGFRSLKEISAGRIYISANRQLCYHHSLNWTKVLRGPTEE
RLDIKHNRPRRDCVAEGKVCDPLCSSGGCWGPGPGQCLSCRNYSRGGVCVTHCNFLNGEP
REFAHEAECFSCHPECQPMEGTATCNGSGSDTCAQCAHFRDGPHCVSSCPHGVLGAKGPI
YKYPDVQNECRPCHENCTQGCKGPELQDCLGQTLVLIGKTHLTMALTVIAGLVVIFMMLG
GTFLYWRGRRIQNKRAMRRYLERGESIEPLDPSEKANKVLARIFKETELRKLKVLGSGVF
GTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIVRLLGLCPG
SSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNV
LLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIHFGKYTHQSDVWSYGVT
VWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKE
LANEFTRMARDPPRYLVIKRESGPGIAPGPEPHGLTNKKLEEVELEPELDLDLDLEAEED
NLATTTLGSALSLPVGTLNRPRGSQSLLSPSSGYMPMNQGNLGESCQESAVSGSSERCPR
PVSLHPMPRGCLASESSEGHVTGSEAELQEKVSMCRSRSRSRSPRPRGDSAYHSQRHSLL
TPVTPLSPPGLEEEDVNGYVMPDTHLKGTPSSREGTLSSVGLSSVLGTEEEDEDEEYEYM
NRRRRHSPPHPPRPSSLEELGYEYMDVGSDLSASLGSTQSCPLHPVPIMPTAGTTPDEDY
EYMNRQRDGGGPGGDYAAMGACPASEQGYEEMRAFQGPGHQAPHVHYARLKTLRSLEATD
SAFDNPDYWHSRLFPKANAQRT

BDBM50461175

n/a

Name

BDBM50461175

Synonyms:

CHEMBL4225565

Type

Small organic molecule

Emp. Form.

C28H33N7OS

Mol. Mass.

515.673

SMILES

CN1CCN(CC1)c1ccc(Nc2ncc3nc(Sc4ccccc4)n([C@H]4CC[C@H](O)CC4)c3n2)cc1 |r,wU:26.27,wD:29.31,(49.16,-41.25,;49.17,-39.71,;47.83,-38.93,;47.84,-37.4,;49.17,-36.63,;50.51,-37.39,;50.5,-38.94,;49.17,-35.09,;47.84,-34.31,;47.84,-32.77,;49.17,-32.01,;49.17,-30.47,;50.51,-29.7,;50.51,-28.16,;51.84,-27.39,;53.17,-28.15,;54.65,-27.67,;55.56,-28.92,;57.1,-28.92,;57.87,-27.59,;59.41,-27.6,;60.18,-26.26,;59.41,-24.93,;57.86,-24.93,;57.1,-26.27,;54.65,-30.18,;55.13,-31.64,;56.63,-31.96,;57.1,-33.43,;56.07,-34.57,;56.54,-36.04,;54.56,-34.24,;54.09,-32.78,;53.17,-29.7,;51.84,-30.47,;50.5,-32.77,;50.51,-34.31,)|

Structure