| Reaction Details |
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 | Report a problem with these data |
| Target | Procathepsin L |
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| Ligand | BDBM50461251 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1771111 (CHEMBL4223223) |
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| IC50 | 334±n/a nM |
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| Citation |  Nizi, E; Sferrazza, A; Fabbrini, D; Nardi, V; Andreini, M; Graziani, R; Gennari, N; Bresciani, A; Paonessa, G; Harper, S Peptidomimetic nitrile inhibitors of malarial protease falcipain-2 with high selectivity against human cathepsins. Bioorg Med Chem Lett28:1540-1544 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Procathepsin L |
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| Name: | Procathepsin L |
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| Synonyms: | CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein |
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| Type: | Enzyme |
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| Mol. Mass.: | 37557.19 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Purchased from Calbiochem (San Diego, CA). |
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| Residue: | 333 |
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| Sequence: | MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIE
LHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDW
REKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNG
GLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVA
TVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKN
SWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
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| BDBM50461251 |
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| n/a |
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| Name | BDBM50461251 |
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| Synonyms: | CHEMBL4228920 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H22N4O2S |
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| Mol. Mass. | 466.554 |
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| SMILES | O=C(NC1(CC1)C#N)[C@H](Cc1nc2ccccc2s1)NC(=O)c1ccc(cc1)-c1ccccc1 |r| |
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| Structure | 
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