| Reaction Details |
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 | Report a problem with these data |
| Target | Falcipain 2 |
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| Ligand | BDBM50461269 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1771108 (CHEMBL4223220) |
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| IC50 | 2.7±n/a nM |
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| Citation |  Nizi, E; Sferrazza, A; Fabbrini, D; Nardi, V; Andreini, M; Graziani, R; Gennari, N; Bresciani, A; Paonessa, G; Harper, S Peptidomimetic nitrile inhibitors of malarial protease falcipain-2 with high selectivity against human cathepsins. Bioorg Med Chem Lett28:1540-1544 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Falcipain 2 |
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| Name: | Falcipain 2 |
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| Synonyms: | Cysteine protease falcipain-2 | Falcipain 2 | Falcipain-2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 55912.60 |
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| Organism: | Plasmodium falciparum |
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| Description: | Recombinant falcipain-2. |
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| Residue: | 484 |
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| Sequence: | MDYNMDYAPHEVISQQGERFVDKYVDRKILKNKKSLLVIISLSVLSVVGFVLFYFTPNSR
KSDLFKNSSVENNNDDYIINSLLKSPNGKKFIVSKIDEALSFYDSKKNDINKYNEGNNNN
NADFKGLSLFKENTPSNNFIHNKDYFINFFDNKFLMNNAEHINQFYMFIKTNNKQYNSPN
EMKERFQVFLQNAHKVNMHNNNKNSLYKKELNRFADLTYHEFKNKYLSLRSSKPLKNSKY
LLDQMNYEEVIKKYRGEENFDHAAYDWRLHSGVTPVKDQKNCGSCWAFSSIGSVESQYAI
RKNKLITLSEQELVDCSFKNYGCNGGLINNAFEDMIELGGICPDGDYPYVSDAPNLCNID
RCTEKYGIKNYLSVPDNKLKEALRFLGPISISVAVSDDFAFYKEGIFDGECGDQLNHAVM
LVGFGMKEIVNPLTKKGEKHYYYIIKNSWGQQWGERGFINIETDESGLMRKCGLGTDAFI
PLIE
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| BDBM50461269 |
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| n/a |
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| Name | BDBM50461269 |
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| Synonyms: | CHEMBL4227166 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H20N6O2 |
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| Mol. Mass. | 400.4332 |
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| SMILES | O=C(NC1(CC1)C#N)[C@H](Cc1cccnc1)NC(=O)c1cccc(c1)-c1ncc[nH]1 |r| |
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| Structure | 
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