| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome c oxidase subunit 2 |
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| Ligand | BDBM50462396 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1774825 (CHEMBL4231817) |
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| IC50 | >100000±n/a nM |
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| Citation |  Pippione, AC; Carnovale, IM; Bonanni, D; Sini, M; Goyal, P; Marini, E; Pors, K; Adinolfi, S; Zonari, D; Festuccia, C; Wahlgren, WY; Friemann, R; Bagnati, R; Boschi, D; Oliaro-Bosso, S; Lolli, ML Potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the benzoisoxazole moiety: application of a bioisosteric scaffold hopping approach to flufenamic acid. Eur J Med Chem150:930-945 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome c oxidase subunit 2 |
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| Name: | Cytochrome c oxidase subunit 2 |
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| Synonyms: | COII | COX2 | COX2_HUMAN | COXII | MT-CO2 | MTCO2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 25555.66 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_530099 |
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| Residue: | 227 |
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| Sequence: | MAHAAQVGLQDATSPIMEELITFHDHALMIIFLICFLVLYALFLTLTTKLTNTNISDAQE
METVWTILPAIILVLIALPSLRILYMTDEVNDPSLTIKSIGHQWYWTYEYTDYGGLIFNS
YMLPPLFLEPGDLRLLDVDNRVVLPIEAPIRMMITSQDVLHSWAVPTLGLKTDAIPGRLN
QTTFTATRPGVYYGQCSEICGANHSFMPIVLELIPLKIFEMGPVFTL
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| BDBM50462396 |
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| n/a |
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| Name | BDBM50462396 |
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| Synonyms: | CHEMBL4238730 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H9F3N2O2 |
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| Mol. Mass. | 294.2287 |
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| SMILES | Oc1noc2ccc(Nc3cccc(c3)C(F)(F)F)cc12 |
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| Structure | 
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