Reaction Details |
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Target | Transient receptor potential cation channel subfamily M member 8 |
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Ligand | BDBM50331290 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1785280 (CHEMBL4256797) |
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IC50 | 6500±n/a nM |
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Citation | Bertamino, A; Iraci, N; Ostacolo, C; Ambrosino, P; Musella, S; Di Sarno, V; Ciaglia, T; Pepe, G; Sala, M; Soldovieri, MV; Mosca, I; Gonzalez-Rodriguez, S; Fernandez-Carvajal, A; Ferrer-Montiel, A; Novellino, E; Taglialatela, M; Campiglia, P; Gomez-Monterrey, I Identification of a Potent Tryptophan-Based TRPM8 Antagonist With in Vivo Analgesic Activity. J Med Chem61:6140-6152 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Transient receptor potential cation channel subfamily M member 8 |
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Name: | Transient receptor potential cation channel subfamily M member 8 |
Synonyms: | Cmr1 | TRPM8_RAT | Transient receptor potential M8 protein (TRPM8) | Transient receptor potential cation channel subfamily M member 8 | Trpm8 |
Type: | Enzyme |
Mol. Mass.: | 127633.53 |
Organism: | Rattus norvegicus (Rat) |
Description: | Q8R455 |
Residue: | 1104 |
Sequence: | MSFEGARLSMRSRRNGTLGSTRTLYSSVSRSTDVSYSESDLVNFIQANFKKRECVFFTRD
SKAMESICKCGYAQSQHIEGTQINQNEKWNYKKHTKEFPTDAFGDIQFETLGKKGKYLRL
SCDTDSETLYELLTQHWHLKTPNLVISVTGGAKNFALKPRMRKIFSRLIYIAQSKGAWIL
TGGTHYGLMKYIGEVVRDNTISRNSEENIVAIGIAAWGMVSNRDTLIRNCDDEGHFSAQY
IMDDFMRDPLYILDNNHTHLLLVDNGCHGHPTVEAKLRNQLEKYISERTSQDSNYGGKIP
IVCFAQGGGRETLKAINTSVKSKIPCVVVEGSGQIADVIASLVEVEDVLTSSMVKEKLVR
FLPRTVSRLPEEEIESWIKWLKEILESPHLLTVIKMEEAGDEVVSSAISYALYKAFSTNE
QDKDNWNGQLKLLLEWNQLDLASDEIFTNDRRWESADLQEVMFTALIKDRPKFVRLFLEN
GLNLQKFLTNEVLTELFSTHFSTLVYRNLQIAKNSYNDALLTFVWKLVANFRRSFWKEDR
SSREDLDVELHDASLTTRHPLQALFIWAILQNKKELSKVIWEQTKGCTLAALGASKLLKT
LAKVKNDINAAGESEELANEYETRAVELFTECYSSDEDLAEQLLVYSCEAWGGSNCLELA
VEATDQHFIAQPGVQNFLSKQWYGEISRDTKNWKIILCLFIIPLVGCGLVSFRKKPIDKH
KKLLWYYVAFFTSPFVVFSWNVVFYIAFLLLFAYVLLMDFHSVPHTPELILYALVFVLFC
DEVRQWYMNGVNYFTDLWNVMDTLGLFYFIAGIVFRLHSSNKSSLYSGRVIFCLDYIIFT
LRLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFLFAVWMVAFGVARQGILRQNEQRWRWIF
RSVIYEPYLAMFGQVPSDVDSTTYDFSHCTFSGNESKPLCVELDEYNLPRFPEWITIPLV
CIYMLSTNILLVNLLVAMFGYTVGIVQENNDQVWKFQRYFLVQEYCNRLNIPFPFVVFAY
FYMVVKKCFKCCCKEKNTESSACCFRNEDNETLAWEGVMKENYLVKINTKANDNAEEMRH
RFRQLDTKLNDLKGLLKEIANKIK
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BDBM50331290 |
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n/a |
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Name | BDBM50331290 |
Synonyms: | CHEMBL1289953 | N-(3-aminopropyl)-2-(3-methylbenzyloxy)-N-(thiophen-2-ylmethyl)benzamide |
Type | Small organic molecule |
Emp. Form. | C23H26N2O2S |
Mol. Mass. | 394.53 |
SMILES | Cc1cccc(COc2ccccc2C(=O)N(CCCN)Cc2cccs2)c1 |
Structure |
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