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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Sodium channel protein type 5 subunit alpha | ||
| Ligand | BDBM50465935 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1789231 (CHEMBL4260965) | ||
| IC50 | 1100±n/a nM | ||
| Citation |  Davoren, JE; Nason, D; Coe, J; Dlugolenski, K; Helal, C; Harris, AR; LaChapelle, E; Liang, S; Liu, Y; O'Connor, R; Orozco, CC; Rai, BK; Salafia, M; Samas, B; Xu, W; Kozak, R; Gray, D Discovery and Lead Optimization of Atropisomer D1 Agonists with Reduced Desensitization. J Med Chem61:11384-11397 (2018) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Sodium channel protein type 5 subunit alpha | |||
| Name: | Sodium channel protein type 5 subunit alpha | ||
| Synonyms: | HH1 | SCN5A | SCN5A_HUMAN | Sodium channel alpha subunit | Sodium channel protein type 5 subunit alpha/beta-1/beta-2 | Sodium channel protein type V alpha subunit | Voltage-gated sodium channel subunit alpha Nav1.5 | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 226908.60 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q14524 | ||
| Residue: | 2016 | ||
| Sequence: |
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| BDBM50465935 | |||
| n/a | |||
| Name | BDBM50465935 | ||
| Synonyms: | CHEMBL4277264 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H16N4O2 | ||
| Mol. Mass. | 356.3773 | ||
| SMILES | Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12 |(29.98,-5.28,;29.99,-6.82,;28.67,-7.59,;28.68,-9.13,;27.35,-9.9,;27.36,-11.44,;28.69,-12.2,;28.7,-13.75,;27.36,-14.52,;26.03,-13.75,;24.57,-14.23,;23.66,-13,;24.55,-11.74,;26.02,-12.21,;30.02,-9.9,;31.35,-9.12,;31.34,-7.58,;32.66,-6.8,;34,-7.57,;34.01,-9.11,;35.33,-6.79,;35.32,-5.25,;33.97,-4.49,;33.64,-2.99,;32.12,-2.84,;31.5,-4.24,;32.64,-5.27,)| | ||
| Structure | 
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