Reaction Details |
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Target | Dual specificity tyrosine-phosphorylation-regulated kinase 1B |
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Ligand | BDBM50466168 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1791713 (CHEMBL4263632) |
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IC50 | 326±n/a nM |
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Citation | Darwish, SS; Abdel-Halim, M; Salah, M; Abadi, AH; Becker, W; Engel, M Development of novel 2,4-bispyridyl thiophene-based compounds as highly potent and selective Dyrk1A inhibitors. Part I: Benzamide and benzylamide derivatives. Eur J Med Chem157:1031-1050 (2018) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Dual specificity tyrosine-phosphorylation-regulated kinase 1B |
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Name: | Dual specificity tyrosine-phosphorylation-regulated kinase 1B |
Synonyms: | DYR1B_HUMAN | DYRK1B | Dual specificity tyrosine-phosphorylation-regulated kinase 1B | Dual-specificity tyrosine-regulated kinases 1B | MIRK |
Type: | Enzyme |
Mol. Mass.: | 69222.24 |
Organism: | Homo sapiens (Human) |
Description: | Q9Y463 |
Residue: | 629 |
Sequence: | MAVPPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHIN
EVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKG
SFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHF
MFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDL
KPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLG
CILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRT
KELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARI
SPLGALQHGFFRRTADEATNTGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSSDN
RTYRYSNRYCGGPGPPITDCEMNSPQVPPSQPLRPWAGGDVPHKTHQAPASASSLPGTGA
QLPPQPRYLGRPPSPTSPPPPELMDVSLVGGPADCSPPHPAPAPQHPAASALRTRMTGGR
PPLPPPDDPATLGPHLGLRGVPQSTAASS
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BDBM50466168 |
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n/a |
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Name | BDBM50466168 |
Synonyms: | CHEMBL4282366 |
Type | Small organic molecule |
Emp. Form. | C22H17N3OS |
Mol. Mass. | 371.455 |
SMILES | O=C(Cc1ccccc1)Nc1cncc(c1)-c1cc(cs1)-c1cccnc1 |
Structure |
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