Found 100 hits with Last Name = 'darwish' and Initial = 'ss' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50237049
(CHEMBL3133904)Show InChI InChI=1S/C18H15FN4O/c1-3-16(24)22-12-7-8-14-13(9-12)18(21-10-20-14)23-15-6-4-5-11(2)17(15)19/h3-10H,1H2,2H3,(H,22,24)(H,20,21,23) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Saarland University
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged EGFR (668 to 1210 residues) cytoplasmic domain expressed in baculovirus expression system |
J Med Chem 60: 2853-2868 (2017)
Article DOI: 10.1021/acs.jmedchem.6b01774
BindingDB Entry DOI: 10.7270/Q2K35WXP |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50237048
(CHEMBL3132872)Show InChI InChI=1S/C17H12BrFN4O/c1-2-16(24)22-11-4-6-14-12(8-11)17(21-9-20-14)23-15-5-3-10(18)7-13(15)19/h2-9H,1H2,(H,22,24)(H,20,21,23) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Saarland University
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged EGFR (668 to 1210 residues) cytoplasmic domain expressed in baculovirus expression system |
J Med Chem 60: 2853-2868 (2017)
Article DOI: 10.1021/acs.jmedchem.6b01774
BindingDB Entry DOI: 10.7270/Q2K35WXP |
More data for this
Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM50469211
(CHEMBL4283503)Show InChI InChI=1S/C18H15N3OS/c22-18(12-3-4-12)21-16-6-14(9-20-10-16)17-7-15(11-23-17)13-2-1-5-19-8-13/h1-2,5-12H,3-4H2,(H,21,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a |
German University in Cairo
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human N-terminal His6-tagged DYRK1A expressed in Escherichia coli BL21(DE3) using KKISGRLSPIMTEQ-NH2 as substrate after 15 ... |
Eur J Med Chem 158: 270-285 (2018)
Article DOI: 10.1016/j.ejmech.2018.08.097
BindingDB Entry DOI: 10.7270/Q2VH5RK5 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM5447
(CHEMBL939 | GEFITINIB | Iressa | N-(3-Chloro-4-flu...)Show SMILES COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1 Show InChI InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| DrugBank
MMDB
PDB
Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Saarland University
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged EGFR (668 to 1210 residues) cytoplasmic domain expressed in baculovirus expression system |
J Med Chem 60: 2853-2868 (2017)
Article DOI: 10.1021/acs.jmedchem.6b01774
BindingDB Entry DOI: 10.7270/Q2K35WXP |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50237123
(CHEMBL4097369)Show InChI InChI=1S/C19H13BrN4O2/c20-12-3-1-4-13(9-12)23-18-15-10-14(6-7-16(15)21-11-22-18)24-19(25)17-5-2-8-26-17/h1-11H,(H,24,25)(H,21,22,23) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Saarland University
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged EGFR (668 to 1210 residues) cytoplasmic domain expressed in baculovirus expression system |
J Med Chem 60: 2853-2868 (2017)
Article DOI: 10.1021/acs.jmedchem.6b01774
BindingDB Entry DOI: 10.7270/Q2K35WXP |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50237111
(CHEMBL4103464)Show SMILES Brc1cccc(Nc2ncnc3ccc(NC(=O)NCc4ccccc4)cc23)c1 Show InChI InChI=1S/C22H18BrN5O/c23-16-7-4-8-17(11-16)27-21-19-12-18(9-10-20(19)25-14-26-21)28-22(29)24-13-15-5-2-1-3-6-15/h1-12,14H,13H2,(H2,24,28,29)(H,25,26,27) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 8.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Saarland University
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged EGFR (668 to 1210 residues) cytoplasmic domain expressed in baculovirus expression system |
J Med Chem 60: 2853-2868 (2017)
Article DOI: 10.1021/acs.jmedchem.6b01774
BindingDB Entry DOI: 10.7270/Q2K35WXP |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50237097
(CHEMBL4075530)Show SMILES Oc1ccc(NC(=S)Nc2ccc3ncnc(Nc4cccc(Br)c4)c3c2)cc1 Show InChI InChI=1S/C21H16BrN5OS/c22-13-2-1-3-15(10-13)25-20-18-11-16(6-9-19(18)23-12-24-20)27-21(29)26-14-4-7-17(28)8-5-14/h1-12,28H,(H,23,24,25)(H2,26,27,29) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Saarland University
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged EGFR (668 to 1210 residues) cytoplasmic domain expressed in baculovirus expression system |
J Med Chem 60: 2853-2868 (2017)
Article DOI: 10.1021/acs.jmedchem.6b01774
BindingDB Entry DOI: 10.7270/Q2K35WXP |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50237186
(CHEMBL4092951)Show InChI InChI=1S/C16H14BrN5S/c1-18-16(23)22-12-5-6-14-13(8-12)15(20-9-19-14)21-11-4-2-3-10(17)7-11/h2-9H,1H3,(H2,18,22,23)(H,19,20,21) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Saarland University
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Dipeptidylpeptidase IV. |
J Med Chem 60: 2853-2868 (2017)
Article DOI: 10.1021/acs.jmedchem.6b01774
BindingDB Entry DOI: 10.7270/Q2K35WXP |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50237098
(CHEMBL4075103)Show SMILES NS(=O)(=O)c1ccc(NC(=S)Nc2ccc3ncnc(Nc4cccc(Br)c4)c3c2)cc1 Show InChI InChI=1S/C21H17BrN6O2S2/c22-13-2-1-3-15(10-13)26-20-18-11-16(6-9-19(18)24-12-25-20)28-21(31)27-14-4-7-17(8-5-14)32(23,29)30/h1-12H,(H2,23,29,30)(H,24,25,26)(H2,27,28,31) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Saarland University
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged EGFR (668 to 1210 residues) cytoplasmic domain expressed in baculovirus expression system |
J Med Chem 60: 2853-2868 (2017)
Article DOI: 10.1021/acs.jmedchem.6b01774
BindingDB Entry DOI: 10.7270/Q2K35WXP |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50237108
(CHEMBL4065288)Show SMILES Brc1cccc(Nc2ncnc3ccc(NC(=S)Nc4cccnc4)cc23)c1 Show InChI InChI=1S/C20H15BrN6S/c21-13-3-1-4-14(9-13)25-19-17-10-15(6-7-18(17)23-12-24-19)26-20(28)27-16-5-2-8-22-11-16/h1-12H,(H,23,24,25)(H2,26,27,28) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Saarland University
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged EGFR (668 to 1210 residues) cytoplasmic domain expressed in baculovirus expression system |
J Med Chem 60: 2853-2868 (2017)
Article DOI: 10.1021/acs.jmedchem.6b01774
BindingDB Entry DOI: 10.7270/Q2K35WXP |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50237124
(CHEMBL4091921)Show SMILES Clc1cccc(Nc2ncnc3ccc(NC(=S)NCc4ccccc4)cc23)c1 Show InChI InChI=1S/C22H18ClN5S/c23-16-7-4-8-17(11-16)27-21-19-12-18(9-10-20(19)25-14-26-21)28-22(29)24-13-15-5-2-1-3-6-15/h1-12,14H,13H2,(H2,24,28,29)(H,25,26,27) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Saarland University
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged EGFR (668 to 1210 residues) cytoplasmic domain expressed in baculovirus expression system |
J Med Chem 60: 2853-2868 (2017)
Article DOI: 10.1021/acs.jmedchem.6b01774
BindingDB Entry DOI: 10.7270/Q2K35WXP |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50179494
(CHEMBL3815163)Show SMILES Brc1cccc(Nc2ncnc3ccc(NC(=S)NCCN4CCOCC4)cc23)c1 Show InChI InChI=1S/C21H23BrN6OS/c22-15-2-1-3-16(12-15)26-20-18-13-17(4-5-19(18)24-14-25-20)27-21(30)23-6-7-28-8-10-29-11-9-28/h1-5,12-14H,6-11H2,(H2,23,27,30)(H,24,25,26) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Saarland University
Curated by ChEMBL
| Assay Description
In vitro inhibition of porcine Dipeptidylpeptidase II. |
J Med Chem 60: 2853-2868 (2017)
Article DOI: 10.1021/acs.jmedchem.6b01774
BindingDB Entry DOI: 10.7270/Q2K35WXP |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase haspin
(Homo sapiens (Human)) | BDBM50466167
(CHEMBL4278808)Show SMILES Oc1ccc(c(F)c1)-c1nc2ccc3[nH]ncc3c2c2CCCCc12 Show InChI InChI=1S/C20H16FN3O/c21-16-9-11(25)5-6-14(16)20-13-4-2-1-3-12(13)19-15-10-22-24-17(15)7-8-18(19)23-20/h5-10,25H,1-4H2,(H,22,24) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
German University in Cairo
Curated by ChEMBL
| Assay Description
Inhibition of Haspin (unknown origin) after 3 hrs by ADP-Glo assay |
Eur J Med Chem 157: 1031-1050 (2018)
Article DOI: 10.1016/j.ejmech.2018.07.050
BindingDB Entry DOI: 10.7270/Q2280B8Q |
More data for this
Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM50466158
(CHEMBL4290247)Show SMILES Fc1ccc(CC(=O)Nc2cncc(c2)-c2cc(cs2)-c2cccnc2)cc1 Show InChI InChI=1S/C22H16FN3OS/c23-19-5-3-15(4-6-19)8-22(27)26-20-9-17(12-25-13-20)21-10-18(14-28-21)16-2-1-7-24-11-16/h1-7,9-14H,8H2,(H,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
German University in Cairo
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human N-terminal His6-tagged DYRK1A expressed in Escherichia coli BL21(DE3) using KKISGRLSPIMTEQ-NH2 as substrate after 15 ... |
Eur J Med Chem 158: 270-285 (2018)
Article DOI: 10.1016/j.ejmech.2018.08.097
BindingDB Entry DOI: 10.7270/Q2VH5RK5 |
More data for this
Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM50466158
(CHEMBL4290247)Show SMILES Fc1ccc(CC(=O)Nc2cncc(c2)-c2cc(cs2)-c2cccnc2)cc1 Show InChI InChI=1S/C22H16FN3OS/c23-19-5-3-15(4-6-19)8-22(27)26-20-9-17(12-25-13-20)21-10-18(14-28-21)16-2-1-7-24-11-16/h1-7,9-14H,8H2,(H,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
German University in Cairo
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human Dyrk1A expressed in Baculovirus expression system by Z'-LYTE assay |
Eur J Med Chem 157: 1031-1050 (2018)
Article DOI: 10.1016/j.ejmech.2018.07.050
BindingDB Entry DOI: 10.7270/Q2280B8Q |
More data for this
Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM50466158
(CHEMBL4290247)Show SMILES Fc1ccc(CC(=O)Nc2cncc(c2)-c2cc(cs2)-c2cccnc2)cc1 Show InChI InChI=1S/C22H16FN3OS/c23-19-5-3-15(4-6-19)8-22(27)26-20-9-17(12-25-13-20)21-10-18(14-28-21)16-2-1-7-24-11-16/h1-7,9-14H,8H2,(H,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
German University in Cairo
Curated by ChEMBL
| Assay Description
Inhibition of recombinant full length human Dyrk1A expressed in Baculovirus expression system using KKISGRLSPIMTEQ as substrate in presence of ATP |
Eur J Med Chem 157: 1031-1050 (2018)
Article DOI: 10.1016/j.ejmech.2018.07.050
BindingDB Entry DOI: 10.7270/Q2280B8Q |
More data for this
Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM50466168
(CHEMBL4282366)Show SMILES O=C(Cc1ccccc1)Nc1cncc(c1)-c1cc(cs1)-c1cccnc1 Show InChI InChI=1S/C22H17N3OS/c26-22(9-16-5-2-1-3-6-16)25-20-10-18(13-24-14-20)21-11-19(15-27-21)17-7-4-8-23-12-17/h1-8,10-15H,9H2,(H,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
German University in Cairo
Curated by ChEMBL
| Assay Description
Inhibition of recombinant full length human Dyrk1A expressed in Baculovirus expression system using KKISGRLSPIMTEQ as substrate in presence of ATP |
Eur J Med Chem 157: 1031-1050 (2018)
Article DOI: 10.1016/j.ejmech.2018.07.050
BindingDB Entry DOI: 10.7270/Q2280B8Q |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50237062
(CHEMBL4076434)Show SMILES Brc1cccc(Nc2ncnc3ccc(NC(=S)Nc4ccccc4)cc23)c1 Show InChI InChI=1S/C21H16BrN5S/c22-14-5-4-8-16(11-14)25-20-18-12-17(9-10-19(18)23-13-24-20)27-21(28)26-15-6-2-1-3-7-15/h1-13H,(H,23,24,25)(H2,26,27,28) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Saarland University
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged EGFR (668 to 1210 residues) cytoplasmic domain expressed in baculovirus expression system |
J Med Chem 60: 2853-2868 (2017)
Article DOI: 10.1021/acs.jmedchem.6b01774
BindingDB Entry DOI: 10.7270/Q2K35WXP |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50237063
(CHEMBL4102455)Show SMILES Clc1ccccc1NC(=S)Nc1ccc2ncnc(Nc3cccc(Br)c3)c2c1 Show InChI InChI=1S/C21H15BrClN5S/c22-13-4-3-5-14(10-13)26-20-16-11-15(8-9-18(16)24-12-25-20)27-21(29)28-19-7-2-1-6-17(19)23/h1-12H,(H,24,25,26)(H2,27,28,29) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Saarland University
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged EGFR (668 to 1210 residues) cytoplasmic domain expressed in baculovirus expression system |
J Med Chem 60: 2853-2868 (2017)
Article DOI: 10.1021/acs.jmedchem.6b01774
BindingDB Entry DOI: 10.7270/Q2K35WXP |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50237047
(CHEMBL4088718)Show SMILES Brc1cccc(Nc2ncnc3ccc(NC(=S)NCc4ccccc4)cc23)c1 Show InChI InChI=1S/C22H18BrN5S/c23-16-7-4-8-17(11-16)27-21-19-12-18(9-10-20(19)25-14-26-21)28-22(29)24-13-15-5-2-1-3-6-15/h1-12,14H,13H2,(H2,24,28,29)(H,25,26,27) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Saarland University
Curated by ChEMBL
| Assay Description
Inhibitory concentration against rabbit muscle glyceraldehyde-3-phosphate dehydrogenase (GAPDH) |
J Med Chem 60: 2853-2868 (2017)
Article DOI: 10.1021/acs.jmedchem.6b01774
BindingDB Entry DOI: 10.7270/Q2K35WXP |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase pim-1
(Homo sapiens (Human)) | BDBM138364
(US10278929, Compound 12 | US11337935, Compound 12 ...)Show InChI InChI=1S/C11H6F3NO2S/c12-11(13,14)7-3-1-2-6(4-7)5-8-9(16)15-10(17)18-8/h1-5H,(H,15,16,17)/b8-5- | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
PDB
UniChem
| Article
PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Saarland University
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant full length His-tagged PIM-1 expressed in baculovirus expression system |
J Med Chem 60: 2853-2868 (2017)
Article DOI: 10.1021/acs.jmedchem.6b01774
BindingDB Entry DOI: 10.7270/Q2K35WXP |
More data for this
Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM50469213
(CHEMBL4278353)Show InChI InChI=1S/C16H14N4OS/c21-16(10-1-2-10)20-14-3-11(5-17-8-14)15-4-12(9-22-15)13-6-18-19-7-13/h3-10H,1-2H2,(H,18,19)(H,20,21) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
German University in Cairo
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human N-terminal His6-tagged DYRK1A expressed in Escherichia coli BL21(DE3) using KKISGRLSPIMTEQ-NH2 as substrate after 15 ... |
Eur J Med Chem 158: 270-285 (2018)
Article DOI: 10.1016/j.ejmech.2018.08.097
BindingDB Entry DOI: 10.7270/Q2VH5RK5 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50237112
(CHEMBL4089588)Show SMILES Clc1ccc(NC(=O)Nc2ccc3ncnc(Nc4cccc(Br)c4)c3c2)cc1 Show InChI InChI=1S/C21H15BrClN5O/c22-13-2-1-3-16(10-13)26-20-18-11-17(8-9-19(18)24-12-25-20)28-21(29)27-15-6-4-14(23)5-7-15/h1-12H,(H,24,25,26)(H2,27,28,29) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Saarland University
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged EGFR (668 to 1210 residues) cytoplasmic domain expressed in baculovirus expression system |
J Med Chem 60: 2853-2868 (2017)
Article DOI: 10.1021/acs.jmedchem.6b01774
BindingDB Entry DOI: 10.7270/Q2K35WXP |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50237096
(CHEMBL4097862)Show SMILES Clc1ccc(NC(=S)Nc2ccc3ncnc(Nc4cccc(Br)c4)c3c2)cc1 Show InChI InChI=1S/C21H15BrClN5S/c22-13-2-1-3-16(10-13)26-20-18-11-17(8-9-19(18)24-12-25-20)28-21(29)27-15-6-4-14(23)5-7-15/h1-12H,(H,24,25,26)(H2,27,28,29) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Saarland University
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged EGFR (668 to 1210 residues) cytoplasmic domain expressed in baculovirus expression system |
J Med Chem 60: 2853-2868 (2017)
Article DOI: 10.1021/acs.jmedchem.6b01774
BindingDB Entry DOI: 10.7270/Q2K35WXP |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50237117
(CHEMBL4078182)Show SMILES Clc1cccc(NC(=S)Nc2ccc3ncnc(Nc4cccc(Br)c4)c3c2)c1 Show InChI InChI=1S/C21H15BrClN5S/c22-13-3-1-5-15(9-13)26-20-18-11-17(7-8-19(18)24-12-25-20)28-21(29)27-16-6-2-4-14(23)10-16/h1-12H,(H,24,25,26)(H2,27,28,29) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Saarland University
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminal GST-tagged EGFR (668 to 1210 residues) expressed in baculovirus infected Sf9 insect cells using KHKKLAEGSA... |
J Med Chem 60: 2853-2868 (2017)
Article DOI: 10.1021/acs.jmedchem.6b01774
BindingDB Entry DOI: 10.7270/Q2K35WXP |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50237121
(CHEMBL4101774)Show SMILES Brc1cccc(Nc2ncnc3ccc(NC(=S)Nc4ccc(cc4)S(=O)(=O)Nc4nccs4)cc23)c1 Show InChI InChI=1S/C24H18BrN7O2S3/c25-15-2-1-3-17(12-15)29-22-20-13-18(6-9-21(20)27-14-28-22)31-23(35)30-16-4-7-19(8-5-16)37(33,34)32-24-26-10-11-36-24/h1-14H,(H,26,32)(H,27,28,29)(H2,30,31,35) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Saarland University
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged EGFR (668 to 1210 residues) cytoplasmic domain expressed in baculovirus expression system |
J Med Chem 60: 2853-2868 (2017)
Article DOI: 10.1021/acs.jmedchem.6b01774
BindingDB Entry DOI: 10.7270/Q2K35WXP |
More data for this
Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM50466164
(CHEMBL4283474)Show SMILES Fc1cc(F)c(C(=O)Nc2cncc(c2)-c2cc(cs2)-c2cccnc2)c(F)c1 Show InChI InChI=1S/C21H12F3N3OS/c22-15-6-17(23)20(18(24)7-15)21(28)27-16-4-13(9-26-10-16)19-5-14(11-29-19)12-2-1-3-25-8-12/h1-11H,(H,27,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
German University in Cairo
Curated by ChEMBL
| Assay Description
Inhibition of recombinant full length human Dyrk1A expressed in Baculovirus expression system using KKISGRLSPIMTEQ as substrate in presence of ATP |
Eur J Med Chem 157: 1031-1050 (2018)
Article DOI: 10.1016/j.ejmech.2018.07.050
BindingDB Entry DOI: 10.7270/Q2280B8Q |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50237099
(CHEMBL4066504)Show SMILES Fc1ccc(NC(=S)Nc2ccc3ncnc(Nc4cccc(Br)c4)c3c2)cc1Cl Show InChI InChI=1S/C21H14BrClFN5S/c22-12-2-1-3-13(8-12)27-20-16-9-14(5-7-19(16)25-11-26-20)28-21(30)29-15-4-6-18(24)17(23)10-15/h1-11H,(H,25,26,27)(H2,28,29,30) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Saarland University
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged EGFR (668 to 1210 residues) cytoplasmic domain expressed in baculovirus expression system |
J Med Chem 60: 2853-2868 (2017)
Article DOI: 10.1021/acs.jmedchem.6b01774
BindingDB Entry DOI: 10.7270/Q2K35WXP |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50237110
(CHEMBL4062528)Show SMILES Brc1cccc(Nc2ncnc3ccc(NC(=S)N4CCOCC4)cc23)c1 Show InChI InChI=1S/C19H18BrN5OS/c20-13-2-1-3-14(10-13)23-18-16-11-15(4-5-17(16)21-12-22-18)24-19(27)25-6-8-26-9-7-25/h1-5,10-12H,6-9H2,(H,24,27)(H,21,22,23) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Saarland University
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged EGFR (668 to 1210 residues) cytoplasmic domain expressed in baculovirus expression system |
J Med Chem 60: 2853-2868 (2017)
Article DOI: 10.1021/acs.jmedchem.6b01774
BindingDB Entry DOI: 10.7270/Q2K35WXP |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50237109
(CHEMBL4071170)Show SMILES Clc1ccc(CNC(=S)Nc2ccc3ncnc(Nc4cccc(Br)c4)c3c2)cc1 Show InChI InChI=1S/C22H17BrClN5S/c23-15-2-1-3-17(10-15)28-21-19-11-18(8-9-20(19)26-13-27-21)29-22(30)25-12-14-4-6-16(24)7-5-14/h1-11,13H,12H2,(H2,25,29,30)(H,26,27,28) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Saarland University
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged EGFR (668 to 1210 residues) cytoplasmic domain expressed in baculovirus expression system |
J Med Chem 60: 2853-2868 (2017)
Article DOI: 10.1021/acs.jmedchem.6b01774
BindingDB Entry DOI: 10.7270/Q2K35WXP |
More data for this
Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM50469215
(CHEMBL4281810)Show SMILES CCn1cc(cn1)-c1csc(c1)-c1cncc(NC(=O)C2CC2)c1 Show InChI InChI=1S/C18H18N4OS/c1-2-22-10-15(8-20-22)14-6-17(24-11-14)13-5-16(9-19-7-13)21-18(23)12-3-4-12/h5-12H,2-4H2,1H3,(H,21,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
German University in Cairo
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human N-terminal His6-tagged DYRK1A expressed in Escherichia coli BL21(DE3) using KKISGRLSPIMTEQ-NH2 as substrate after 15 ... |
Eur J Med Chem 158: 270-285 (2018)
Article DOI: 10.1016/j.ejmech.2018.08.097
BindingDB Entry DOI: 10.7270/Q2VH5RK5 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50237188
(CHEMBL4088760)Show SMILES Brc1ccc(NC(=S)Nc2ccc3ncnc(Nc4cccc(Br)c4)c3c2)cc1 Show InChI InChI=1S/C21H15Br2N5S/c22-13-4-6-15(7-5-13)27-21(29)28-17-8-9-19-18(11-17)20(25-12-24-19)26-16-3-1-2-14(23)10-16/h1-12H,(H,24,25,26)(H2,27,28,29) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
Saarland University
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminal GST-tagged EGFR (668 to 1210 residues) expressed in baculovirus infected Sf9 insect cells using KHKKLAEGSA... |
J Med Chem 60: 2853-2868 (2017)
Article DOI: 10.1021/acs.jmedchem.6b01774
BindingDB Entry DOI: 10.7270/Q2K35WXP |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase haspin
(Homo sapiens (Human)) | BDBM50466158
(CHEMBL4290247)Show SMILES Fc1ccc(CC(=O)Nc2cncc(c2)-c2cc(cs2)-c2cccnc2)cc1 Show InChI InChI=1S/C22H16FN3OS/c23-19-5-3-15(4-6-19)8-22(27)26-20-9-17(12-25-13-20)21-10-18(14-28-21)16-2-1-7-24-11-16/h1-7,9-14H,8H2,(H,26,27) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
German University in Cairo
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human Haspin expressed in Baculovirus expression system by Adapta assay |
Eur J Med Chem 157: 1031-1050 (2018)
Article DOI: 10.1016/j.ejmech.2018.07.050
BindingDB Entry DOI: 10.7270/Q2280B8Q |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50237052
(CHEMBL4072769)Show SMILES Cc1cccc(Nc2ncnc3ccc(NC(=S)NCc4ccccc4)cc23)c1 Show InChI InChI=1S/C23H21N5S/c1-16-6-5-9-18(12-16)27-22-20-13-19(10-11-21(20)25-15-26-22)28-23(29)24-14-17-7-3-2-4-8-17/h2-13,15H,14H2,1H3,(H2,24,28,29)(H,25,26,27) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 37 | n/a | n/a | n/a | n/a | n/a | n/a |
Saarland University
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged EGFR (668 to 1210 residues) cytoplasmic domain expressed in baculovirus expression system |
J Med Chem 60: 2853-2868 (2017)
Article DOI: 10.1021/acs.jmedchem.6b01774
BindingDB Entry DOI: 10.7270/Q2K35WXP |
More data for this
Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM50466157
(CHEMBL4294049)Show SMILES COc1ccc(C(=O)Nc2cncc(c2)-c2cc(cs2)-c2cccnc2)c(F)c1 Show InChI InChI=1S/C22H16FN3O2S/c1-28-18-4-5-19(20(23)9-18)22(27)26-17-7-15(11-25-12-17)21-8-16(13-29-21)14-3-2-6-24-10-14/h2-13H,1H3,(H,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 37 | n/a | n/a | n/a | n/a | n/a | n/a |
German University in Cairo
Curated by ChEMBL
| Assay Description
Inhibition of recombinant full length human Dyrk1A expressed in Baculovirus expression system using KKISGRLSPIMTEQ as substrate in presence of ATP |
Eur J Med Chem 157: 1031-1050 (2018)
Article DOI: 10.1016/j.ejmech.2018.07.050
BindingDB Entry DOI: 10.7270/Q2280B8Q |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50237117
(CHEMBL4078182)Show SMILES Clc1cccc(NC(=S)Nc2ccc3ncnc(Nc4cccc(Br)c4)c3c2)c1 Show InChI InChI=1S/C21H15BrClN5S/c22-13-3-1-5-15(9-13)26-20-18-11-17(7-8-19(18)24-12-25-20)28-21(29)27-16-6-2-4-14(23)10-16/h1-12H,(H,24,25,26)(H2,27,28,29) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
Saarland University
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged EGFR (668 to 1210 residues) cytoplasmic domain expressed in baculovirus expression system |
J Med Chem 60: 2853-2868 (2017)
Article DOI: 10.1021/acs.jmedchem.6b01774
BindingDB Entry DOI: 10.7270/Q2K35WXP |
More data for this
Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM50469211
(CHEMBL4283503)Show InChI InChI=1S/C18H15N3OS/c22-18(12-3-4-12)21-16-6-14(9-20-10-16)17-7-15(11-23-17)13-2-1-5-19-8-13/h1-2,5-12H,3-4H2,(H,21,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
German University in Cairo
Curated by ChEMBL
| Assay Description
Inhibition of DYRK1A in human HeLa cells harboring GFP-SF3b1-NT assessed as reduction in SF3b1 phosphorylation at T343 residue after 18 hrs by Wester... |
Eur J Med Chem 158: 270-285 (2018)
Article DOI: 10.1016/j.ejmech.2018.08.097
BindingDB Entry DOI: 10.7270/Q2VH5RK5 |
More data for this
Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM50469218
(CHEMBL4287985)Show InChI InChI=1S/C12H8N2S2/c1-2-9(5-13-3-1)11-4-10(7-15-11)12-6-14-8-16-12/h1-8H | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
German University in Cairo
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human N-terminal His6-tagged DYRK1A expressed in Escherichia coli BL21(DE3) using KKISGRLSPIMTEQ-NH2 as substrate after 15 ... |
Eur J Med Chem 158: 270-285 (2018)
Article DOI: 10.1016/j.ejmech.2018.08.097
BindingDB Entry DOI: 10.7270/Q2VH5RK5 |
More data for this
Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM50469214
(CHEMBL4292442)Show InChI InChI=1S/C17H16N4OS/c1-21-9-14(7-19-21)13-5-16(23-10-13)12-4-15(8-18-6-12)20-17(22)11-2-3-11/h4-11H,2-3H2,1H3,(H,20,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
German University in Cairo
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human N-terminal His6-tagged DYRK1A expressed in Escherichia coli BL21(DE3) using KKISGRLSPIMTEQ-NH2 as substrate after 15 ... |
Eur J Med Chem 158: 270-285 (2018)
Article DOI: 10.1016/j.ejmech.2018.08.097
BindingDB Entry DOI: 10.7270/Q2VH5RK5 |
More data for this
Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM50466169
(CHEMBL4295177)Show SMILES Fc1ccc(C(=O)Nc2cncc(c2)-c2cc(cs2)-c2cccnc2)c(F)c1 Show InChI InChI=1S/C21H13F2N3OS/c22-16-3-4-18(19(23)8-16)21(27)26-17-6-14(10-25-11-17)20-7-15(12-28-20)13-2-1-5-24-9-13/h1-12H,(H,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 49 | n/a | n/a | n/a | n/a | n/a | n/a |
German University in Cairo
Curated by ChEMBL
| Assay Description
Inhibition of recombinant full length human Dyrk1A expressed in Baculovirus expression system using KKISGRLSPIMTEQ as substrate in presence of ATP |
Eur J Med Chem 157: 1031-1050 (2018)
Article DOI: 10.1016/j.ejmech.2018.07.050
BindingDB Entry DOI: 10.7270/Q2280B8Q |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50237105
(CHEMBL4067514)Show SMILES Clc1ccc(NC(=S)Nc2ccc3ncnc(Nc4cccc(Br)c4)c3c2)c(Cl)c1 Show InChI InChI=1S/C21H14BrCl2N5S/c22-12-2-1-3-14(8-12)27-20-16-10-15(5-7-18(16)25-11-26-20)28-21(30)29-19-6-4-13(23)9-17(19)24/h1-11H,(H,25,26,27)(H2,28,29,30) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 49 | n/a | n/a | n/a | n/a | n/a | n/a |
Saarland University
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged EGFR (668 to 1210 residues) cytoplasmic domain expressed in baculovirus expression system |
J Med Chem 60: 2853-2868 (2017)
Article DOI: 10.1021/acs.jmedchem.6b01774
BindingDB Entry DOI: 10.7270/Q2K35WXP |
More data for this
Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM50466159
(CHEMBL4292471)Show SMILES Cc1ccc(cc1)C(=O)Nc1cncc(c1)-c1cc(cs1)-c1cccnc1 Show InChI InChI=1S/C22H17N3OS/c1-15-4-6-16(7-5-15)22(26)25-20-9-18(12-24-13-20)21-10-19(14-27-21)17-3-2-8-23-11-17/h2-14H,1H3,(H,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 51 | n/a | n/a | n/a | n/a | n/a | n/a |
German University in Cairo
Curated by ChEMBL
| Assay Description
Inhibition of recombinant full length human Dyrk1A expressed in Baculovirus expression system using KKISGRLSPIMTEQ as substrate in presence of ATP |
Eur J Med Chem 157: 1031-1050 (2018)
Article DOI: 10.1016/j.ejmech.2018.07.050
BindingDB Entry DOI: 10.7270/Q2280B8Q |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50237113
(CHEMBL4092966)Show SMILES Clc1cccc(Nc2ncnc3ccc(NC(=S)Nc4cncc(Cl)c4)cc23)c1 Show InChI InChI=1S/C20H14Cl2N6S/c21-12-2-1-3-14(6-12)26-19-17-8-15(4-5-18(17)24-11-25-19)27-20(29)28-16-7-13(22)9-23-10-16/h1-11H,(H,24,25,26)(H2,27,28,29) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 56 | n/a | n/a | n/a | n/a | n/a | n/a |
Saarland University
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged EGFR (668 to 1210 residues) cytoplasmic domain expressed in baculovirus expression system |
J Med Chem 60: 2853-2868 (2017)
Article DOI: 10.1021/acs.jmedchem.6b01774
BindingDB Entry DOI: 10.7270/Q2K35WXP |
More data for this
Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human)) | BDBM50469217
(CHEMBL4294080)Show InChI InChI=1S/C19H17N3OS/c23-19(13-3-1-4-13)22-17-7-15(10-21-11-17)18-8-16(12-24-18)14-5-2-6-20-9-14/h2,5-13H,1,3-4H2,(H,22,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 58 | n/a | n/a | n/a | n/a | n/a | n/a |
German University in Cairo
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human N-terminal His6-tagged DYRK1A expressed in Escherichia coli BL21(DE3) using KKISGRLSPIMTEQ-NH2 as substrate after 15 ... |
Eur J Med Chem 158: 270-285 (2018)
Article DOI: 10.1016/j.ejmech.2018.08.097
BindingDB Entry DOI: 10.7270/Q2VH5RK5 |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50237187
(CHEMBL4065300)Show SMILES Fc1cc(F)cc(NC(=S)Nc2ccc3ncnc(Nc4cccc(Cl)c4)c3c2)c1 Show InChI InChI=1S/C21H14ClF2N5S/c22-12-2-1-3-15(6-12)27-20-18-10-16(4-5-19(18)25-11-26-20)28-21(30)29-17-8-13(23)7-14(24)9-17/h1-11H,(H,25,26,27)(H2,28,29,30) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Saarland University
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant N-terminal GST-tagged EGFR (668 to 1210 residues) expressed in baculovirus infected Sf9 insect cells using KHKKLAEGSA... |
J Med Chem 60: 2853-2868 (2017)
Article DOI: 10.1021/acs.jmedchem.6b01774
BindingDB Entry DOI: 10.7270/Q2K35WXP |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50237102
(CHEMBL4085352)Show SMILES FC(F)(F)c1cccc(NC(=S)Nc2ccc3ncnc(Nc4cccc(Br)c4)c3c2)c1 Show InChI InChI=1S/C22H15BrF3N5S/c23-14-4-2-6-16(10-14)29-20-18-11-17(7-8-19(18)27-12-28-20)31-21(32)30-15-5-1-3-13(9-15)22(24,25)26/h1-12H,(H,27,28,29)(H2,30,31,32) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 61 | n/a | n/a | n/a | n/a | n/a | n/a |
Saarland University
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged EGFR (668 to 1210 residues) cytoplasmic domain expressed in baculovirus expression system |
J Med Chem 60: 2853-2868 (2017)
Article DOI: 10.1021/acs.jmedchem.6b01774
BindingDB Entry DOI: 10.7270/Q2K35WXP |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50237058
(CHEMBL4080711)Show SMILES Oc1cccc(Nc2ncnc3ccc(NC(=S)NCc4ccccc4)cc23)c1 Show InChI InChI=1S/C22H19N5OS/c28-18-8-4-7-16(11-18)26-21-19-12-17(9-10-20(19)24-14-25-21)27-22(29)23-13-15-5-2-1-3-6-15/h1-12,14,28H,13H2,(H2,23,27,29)(H,24,25,26) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 64 | n/a | n/a | n/a | n/a | n/a | n/a |
Saarland University
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant GST-tagged EGFR (668 to 1210 residues) cytoplasmic domain expressed in baculovirus expression system |
J Med Chem 60: 2853-2868 (2017)
Article DOI: 10.1021/acs.jmedchem.6b01774
BindingDB Entry DOI: 10.7270/Q2K35WXP |
More data for this
Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1B
(Homo sapiens (Human)) | BDBM50469214
(CHEMBL4292442)Show InChI InChI=1S/C17H16N4OS/c1-21-9-14(7-19-21)13-5-16(23-10-13)12-4-15(8-18-6-12)20-17(22)11-2-3-11/h4-11H,2-3H2,1H3,(H,20,22) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 67 | n/a | n/a | n/a | n/a | n/a | n/a |
German University in Cairo
Curated by ChEMBL
| Assay Description
Inhibition of full length recombinant human GST-tagged DYRK1B expressed in baculovirus expression system using KKISGRLSPIMTEQ-NH2 as substrate after ... |
Eur J Med Chem 158: 270-285 (2018)
Article DOI: 10.1016/j.ejmech.2018.08.097
BindingDB Entry DOI: 10.7270/Q2VH5RK5 |
More data for this
Ligand-Target Pair | |
Dual specificity tyrosine-phosphorylation-regulated kinase 1B
(Homo sapiens (Human)) | BDBM50469211
(CHEMBL4283503)Show InChI InChI=1S/C18H15N3OS/c22-18(12-3-4-12)21-16-6-14(9-20-10-16)17-7-15(11-23-17)13-2-1-5-19-8-13/h1-2,5-12H,3-4H2,(H,21,22) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 73 | n/a | n/a | n/a | n/a | n/a | n/a |
German University in Cairo
Curated by ChEMBL
| Assay Description
Inhibition of full length recombinant human GST-tagged DYRK1B expressed in baculovirus expression system using KKISGRLSPIMTEQ-NH2 as substrate after ... |
Eur J Med Chem 158: 270-285 (2018)
Article DOI: 10.1016/j.ejmech.2018.08.097
BindingDB Entry DOI: 10.7270/Q2VH5RK5 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase haspin
(Homo sapiens (Human)) | BDBM50469211
(CHEMBL4283503)Show InChI InChI=1S/C18H15N3OS/c22-18(12-3-4-12)21-16-6-14(9-20-10-16)17-7-15(11-23-17)13-2-1-5-19-8-13/h1-2,5-12H,3-4H2,(H,21,22) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 76 | n/a | n/a | n/a | n/a | n/a | n/a |
German University in Cairo
Curated by ChEMBL
| Assay Description
Inhibition of human GST-tagged haspin expressed in baculovirus expression system in presence of 100 uM ATP |
Eur J Med Chem 158: 270-285 (2018)
Article DOI: 10.1016/j.ejmech.2018.08.097
BindingDB Entry DOI: 10.7270/Q2VH5RK5 |
More data for this
Ligand-Target Pair | |
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