| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein phosphatase non-receptor type 12 |
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| Ligand | BDBM50466479 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1793234 (CHEMBL4265153) |
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| IC50 | >50000±n/a nM |
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| Citation |  Sens, L; de Souza, ACA; Pacheco, LA; Menegatti, ACO; Mori, M; Mascarello, A; Nunes, RJ; Terenzi, H Synthetic thiosemicarbazones as a new class of Mycobacterium tuberculosis protein tyrosine phosphatase A inhibitors. Bioorg Med Chem26:5742-5750 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein phosphatase non-receptor type 12 |
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| Name: | Tyrosine-protein phosphatase non-receptor type 12 |
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| Synonyms: | PTN12_HUMAN | PTP-PEST | PTPG1 | PTPN12 | Protein-tyrosine phosphatase G1 | Tyrosine-protein phosphatase non-receptor type 12 | Tyrosine-protein phosphatase non-receptor type 12 (PTP-PEST) |
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| Type: | Protein |
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| Mol. Mass.: | 88089.78 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q05209 |
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| Residue: | 780 |
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| Sequence: | MEQVEILRKFIQRVQAMKSPDHNGEDNFARDFMRLRRLSTKYRTEKIYPTATGEKEENVK
KNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRM
IWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPITFAPFKISCEDEQARTDYFIRTLLL
EFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGA
ICAIDYTWNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQLQL
YEIHGAQKIADGVNEINTENMVSSIEPEKQDSPPPKPPRTRSCLVEGDAKEEILQPPEPH
PVPPILTPSPPSAFPTVTTVWQDNDRYHPKPVLHMVSSEQHSADLNRNYSKSTELPGKNE
STIEQIDKKLERNLSFEIKKVPLQEGPKSFDGNTLLNRGHAIKIKSASPCIADKISKPQE
LSSDLNVGDTSQNSCVDCSVTQSNKVSVTPPEESQNSDTPPRPDRLPLDEKGHVTWSFHG
PENAIPIPDLSEGNSSDINYQTRKTVSLTPSPTTQVETPDLVDHDNTSPLFRTPLSFTNP
LHSDDSDSDERNSDGAVTQNKTNISTASATVSAATSTESISTRKVLPMSIARHNIAGTTH
SGAEKDVDVSEDSPPPLPERTPESFVLASEHNTPVRSEWSELQSQERSEQKKSEGLITSE
NEKCDHPAGGIHYEMCIECPPTFSDKREQISENPTEATDIGFGNRCGKPKGPRDPPSEWT
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| BDBM50466479 |
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| n/a |
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| Name | BDBM50466479 |
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| Synonyms: | CHEMBL4280516 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H19N3S |
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| Mol. Mass. | 381.493 |
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| SMILES | S=C(N\N=C\c1ccc(cc1)-c1ccccc1)Nc1cccc2ccccc12 |
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| Structure | 
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