| Reaction Details |
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 | Report a problem with these data |
| Target | Nuclear receptor ROR-beta |
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| Ligand | BDBM50466986 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1794704 (CHEMBL4266821) |
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| IC50 | 200±n/a nM |
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| Citation |  Doebelin, C; Patouret, R; Garcia-Ordonez, RD; Chang, MR; Dharmarajan, V; Novick, S; Ciesla, A; Campbell, S; Solt, LA; Griffin, PR; Kamenecka, TM Identification of potent ROR? modulators: Scaffold variation. Bioorg Med Chem Lett28:3210-3215 (2018) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Nuclear receptor ROR-beta |
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| Name: | Nuclear receptor ROR-beta |
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| Synonyms: | NR1F2 | Nuclear receptor RZR-beta | Nuclear receptor subfamily 1 group F member 2 | RORB | RORB_HUMAN | RZRB | Retinoid-related orphan receptor-beta |
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| Type: | PROTEIN |
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| Mol. Mass.: | 53227.30 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_107979 |
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| Residue: | 470 |
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| Sequence: | MCENQLKTKADATAQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQNNASYSCPRQ
RNCLIDRTNRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLYAEVQKHQQRLQEQRQ
QQSGEAEALARVYSSSISNGLSNLNNETSGTYANGHVIDLPKSEGYYNVDSGQPSPDQSG
LDMTGIKQIKQEPIYDLTSVPNLFTYSSFNNGQLAPGITMTEIDRIAQNIIKSHLETCQY
TMEELHQLAWQTHTYEEIKAYQSKSREALWQQCAIQITHAIQYVVEFAKRITGFMELCQN
DQILLLKSGCLEVVLVRMCRAFNPLNNTVLFEGKYGGMQMFKALGSDDLVNEAFDFAKNL
CSLQLTEEEIALFSSAVLISPDRAWLIEPRKVQKLQEKIYFALQHVIQKNHLDDETLAKL
IAKIPTITAVCNLHGEKLQVFKQSHPEIVNTLFPPLYKELFNPDCATGCK
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| BDBM50466986 |
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| n/a |
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| Name | BDBM50466986 |
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| Synonyms: | CHEMBL4276733 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H13Cl2NO2S |
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| Mol. Mass. | 378.272 |
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| SMILES | COc1ccccc1C(=O)c1sc(N)cc1-c1cc(Cl)cc(Cl)c1 |
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| Structure | 
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